Transcription Factors

ISBN-13: 9783540210955 / Angielski / Twarda / 2004 / 581 str.

M. Gossen; J. Kaufmann; S. J. Triezenberg

Opis

The present volume, authored by leading experts in the field, contains in-depth information regarding the role of transcription factors as key players in the execution of the genomic program of any given cell. Many of the chapters focus on the role of transcription factors in cellular transformation and cancer, other chapters highlight the contributions of transcription factors to inflammatory responses or xenobiotic responses. Moreover, the volume illustrates how a viral transcription factor interferes with the physiology of its host cell and finally points out how much exciting research transcription factor biology still has to offer.

Spis treści

Part 1: An Introduction to Transcription Factors.- Mechanisms of Transcriptional Activation In Eukaryotes. Multiple Mechanisms of Transcriptional Repression in Eukaryotes. Genomics and Transcription Factors.- Part 2: Transcription Factors in Pathophysiology.- Biological Roles of STAT Family in Cytokine Signalling . Members of the T-Cell Factor Family of DNA Binding Proteins and Their Roles in Tumorigenesis. Transcription Factors in the Control of Tumor Development and Progression by TGF-ß Signalling. The p53 Transcription Factor as Therapeutic Target in Cancer. The Role of Ets Transcription Factors in Mediating Cellular Transformation. Function of E2F-Transcription Factor Family During Normal and Pathological Growth. c-Myc in Cellular Transformation and Cancer. Critical Regulator of Inflammation and the Immune Response. Hepatitis B Virus X Protein (HBx): Structure-Function Relationships and Role in Viral Pathogenesis. Regulation of Xenobiotic detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology.- Part 3: Exogenous Control of Transcription Factor Activity.- Potential of Transcription Factor Decoy OligonucleotidesaAs Therapeutic Approach. Selective Estrogen Receptor Modulators (SERMs) as Therapeutic Agents in Breast Cancer Treatment. Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine. Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications. Modulating Transcription With Artificial Regulators.