The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.

This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years. The volume serves as a useful compendium of current concepts and an inspiring starting point. It is a source for students interested in this emerging field as well as for experienced scientists looking for an update.

After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.

This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on...

"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's...

Reports the developments in rendering, visualization, and rasterization hardware. This book contains contributions to the Sixth Eurographics Workshop on Graphics Hardware, held in Vienna in September 1991.

It is now widely accepted that glutamate is the major excitatory neurotrans mitter in the mammalian central nervous system. The main criteria for accept ing a molecule as a chemical transmitter appear to be fulfilled at several synapses: Glutamate mimics the action of the natural transmitter in the post synaptic neuron (CURTIS et al. 1959), glutamate is present in presynaptic ele ments (OTTERSEN and STORM-MATHISEN 1984), and glutamate is released from central neurons in an activity-dependent manner (BRADFORD 1970). The postsynaptic receptors that mediate the effects of glutamate are markedly...

This monograph deals with recent questions of conformal geometry. It provides in detail an approach to studying moduli spaces of conformal structures, using a new canonical metric for conformal structures. This book is accessible to readers with basic knowledge in differential geometry and global analysis. It addresses graduates and researchers.

This book deals with the presentation and systematic design of mathematical proofs, including correctness proofs of algorithms. Its purpose is to show how completeness of argument, an important constraint especially for the correctness of algorithms, can be combined with brevity. The author stresses that the use of formalism is indispensible for achieving this.

Geometry is a powerful tool to solve a great number of problems in robotics and computer vision. Impressive results have been obtained in these fields in the last decade. It is a new challenge to solve problems of the actual world which require the ability to reason about uncertainty and complex motion constraints by combining geometric, kinematic, and dynamic characteristics. A necessary step is to develop appropriate geometric reasoning techniques with reasonable computational complexity. This volume is based on a workshop held in Grenoble, France, in September 1991. It contains selected...