Neurotransmitter Transporters

ISBN-13: 9783540297833 / Angielski / Twarda / 2006 / 552 str.

Sitte; Harald H. Sitte; Michael Freissmuth

Opis

This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years. The volume serves as a useful compendium of current concepts and an inspiring starting point. It is a source for students interested in this emerging field as well as for experienced scientists looking for an update.

Spis treści

The Molecular Basis of Neurotransmitter Transport.- Zn2+ Modulation of Neurotransmitter Transporters. Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrations to Study Binding Kinetics and Stoichiometry in Transporters. Structure/Function Relationship in the SERT. The Importance of Company – Na+ and CI – Influence Substrate Interaction with SLC6 Transporters and Other Proteins. Currents in Neurotransmitter Transporters. Mutational Analysis of Glutamate Transporters. The Diverse Roles of Vesicular Glutamate Transporters 3. Extraneuronal Monoamine Transporter and Organic Citation Transporters 1 and 2 – A Review of Transport Efficiency.- Regulation of Neurotransmitter Transporters.- The Role of SNARE Proteins in Trafficking and Function of Neurotransmitter Transporters. Regulation of the Dopamine Transporter by Phosphorylation. The Dopamine Transporter - A Vigilant Border Control for Psychostimulant Action. Oligomerization of Neurotransmitter Transporters - A Ticket From the Endoplasmic Reticulum to the Plasma Membrane. Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated Trafficking. Regulation and Dysregulation of Glutamate Transporters. Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle Associated Trimeric G Proteins – New Jobs for Long Known Signal Transduction Molecules.- Genetics, Behaviour and Disease.- Human Genetics and Pharmacology of Neurotransmitter Transporters. Attention Deficit Hyperactivity Disorder (ADHD) and The Dopamine Transporter: Are There Reasons to Pay Attention?. Inactivation of Serotonin (5HT) Transport in Mice: Modeling Altered 5HT Homeostatis Implicated in Emotional Dysfunction, Affective Disorders, and Somatic Syndromes. Lessons From the Knocked-Out Glycine Transporters. The Norepinephrine Transporters in Physiology and Disease. The High-Affinity Choline Transporter(CHT) – A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice.