Carbohydrate-Based Drug Discovery

ISBN-13: 9783527306329 / Angielski / Twarda / 2003 / 980 str.

Chi-Huey Wong; Chi-Huey Wong; Catherine Wong

Opis

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential.
Topics include the following:
> Chemical Synthesis of Carbohydrates
> Carbohydrate Biosynthesis and Metabolism
> Carbohydrate Analysis
> Cellular Functions of Carbohydrates
> Development of Carbohydrate-based Drugs
A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Recenzje

"In summary, Carbohydrate–Based Drug Discovery Vols. 1 and 2 provide an appropriate and useful look at the current state of the art in this relevant and rapidly advancing field. I recommend the book to both experts and less expert readers."

Francesco Nicotra, Università di Milano–Bicocca (Italy)
ChemBioChem 4/2004

"To summarize, the work provides a comprehensive and excellent survey of the present situation in carbohydrate research, in which many interesting details can be spotted. Because of the wide range of topics covered, the reader will refer to it again and again. It is likely to become a standard work on the subject, not exclusively for carbohydrate chemistry enthusiasts."

Oliver Plettenburg, Ulrich Stilz
Angewandte Chemie + IE 2004–43/31

Spis treści

Complex Carbohydrate Synthesis
The Chemistry of Sialic Acid
Solid–Phase Oligosaccharide Synthesis
Solution and Polymer–supported Synthesis of Carbohydrates
Enzymatic Synthesis of Oligosaccharides
Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
Chemistry and Biochemistry of Asparagine–linked Protein Glycosylation
Conformational Analysis of C–Glycosides and Related Compounds
Synthetic Lipid A Analogs for Sepsis Treatment
Polysialic Acid Vaccines
Synthetic Carbohydrate–based Vaccines
Antithrombotics Based on Synthetic Oligosaccharides
Sequencing of Oligosaccharides and Glycoproteins
Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
Glycosyltransferase Inhibitors
RNA–Aminoglycoside Interactions
Glycosylated Natural Products
Small Molecule Inhibitors of the Sulfotransferases
Carbohydrate–based Treatment of Cancer Metastasis
N–Acetylneuraminic Acid Derivatives and Mimetics as Anti–influenza Agents
Carbohydrate–based Drug Discovery in the Battle Against Bacterial Infections

(partial contents)

O autorze

Professor Chi–Huey Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. in Chemistry (with George Whitesides) from Massachusetts Institute of Technology in 1982. He started his independent career as Assistant Professor of Chemistry at Texas A&M University in 1983, where he became Full Professor in 1987. He has been Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute since 1989 and is also a member of the Skaggs Institute for Chemical Biology since 1996.
Professor Wong is a member of the U.S. National Academy of Sciences and the American Academy of Arts and Sciences. He is a recipient of The Searle Scholar Award in Biomedical Sciences (1985), the Presidential Young Investigator Award in Chemistry (1986), the American Chemical Society A.C. Cope Scholar Award (1993), the Roy Whistler Award of the International Carbohydrate Organization (1994), the American Chemical Society Harrison Howe Award in Chemistry (1998) and the Claude S. Hudson Award in Carbohydrate Chemistry (1999), the International Enzyme Engineering Award (1999) and the Presidential Green Chemistry Challenge Award (2000). He is a member of Academia Sinica, Taipei (1994), the American Academy of Arts and Sciences (1996) and the US National Academy of Sciences (2002). He serves as editor–in–chief of Bioorganic and Medicinal Chemistry and is an executive board member of the Tetrahedron Publications. He was head of the Frontier Research Program on Glycotechnology at RIKEN (Institute of Physical and Chemical Research, Japan) (1991–1999) and is currently a scientific advisor of the Max–Planck Institute, a board member of the U.S. National Research Council on Chemical Sciences and Technology, and is a founding scientist of Optimer Pharmaceuticals, Inc. He is author and co–author of over 450 publications, 60 patents and several books.
His current interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including development of new synthetic chemistry based on enzymatic and chemo–enzymatic reactions, synthetic approach to carbohydrate–mediated biological recognition, design and synthesis of mechanism–based inhibitors of enzymes, RNA and carbohydrate receptors, development of oligosaccharide and aminoglycoside microarrays for high–throughput screening and the study of reaction mechanisms.

Blurb

Carbohydrates play a central role in metabolism, cell–cell recognition, and pathogen defense. To exploit the full potential of this diverse compound class for the development of pharmaceutically active substances, this handbook brings together the latest in carbohydrate chemistry with recent knowledge on the biological function of carbohydrates and their derivatives.
Particular emphasis is placed on carbohydrates with pharmaceutical potential, including the most promising carbohydrate–based therapies currently available.

From the Contents:
∗ Complex Carbohydrate Synthesis
∗ Solid–Phase Carbohydrate Synthesis
∗ Glycopeptides and Glycoproteins
∗ Synthetic Carbohydrate–based Vaccines and Antibiotics
∗ Carbohydrate Mimetics
∗ Sequencing of Oligosaccharides and Glycoproteins
∗ Carbohydrate Microarrays
∗ Multivalent Carbohydrate Ligands
∗ Glycosylated Natural Products
∗ Glycosyltransferase Inhibitors
∗ Sulfotransferase Inhibitors
∗ Carbohydrate–based Treatment of Cancer
∗ N–Acetylneuraminic Acid Derivatives as Anti–influenza Agents
∗ Aminoglycosides and Macrolides in RNA Recognition

A premier resource for carbohydrate chemists and drug developers, this comprehensive two–volume handbook contains contributions by more than 80 leading carbohydrate chemists.