Protein Geometry, Classification, Topology and Symmetry : A Computational Analysis of Structure

ISBN-13: 9780750309851 / Angielski / Twarda / 2004 / 348 str.

William R. Taylor; Andras Aszodi; W. R. Taylor

Opis

In this book structural principals of proteins are reviewed and analysed from a geometric perspective with the aim of revealing the underlying regularities in their construction. - Willie Taylor - a recognised leader in mathematical biology/theoretical molecular biology - Protein folding determines function of protein - key research area in molecular biology and biochemistry. Computational power now means problems governing folding can be handled quantitatively. - Reviews principles of protein folding and computational techniques employed - A key area of biophysics - interfaces with many other disciplines. "The work is aimed at readers from the physical sciences and each topic is explained from first principles with an emphasis on basic concepts rather than applications. Despite this, little technical or mathematical knowledge is required and the methods should be easily accessible to readers with a more biological background. While the book would be suitable as a source of projects for undergraduate courses, it is primarily aimed at students on post-graduate courses (MSc, MRes, PhD) and researchers involved in investigation of protein structures."--BOOK JACKET. Title Summary field provided by Blackwell North America, Inc. All Rights Reserved (Blackwell)

Spis treści

1 Introduction

PART 1 - GEOMETRY: Ellipsoids and embedding. Sticks to strings. PART 2 - CLASSIFICATION: Networks and domains. Protein structure comparison. Classiffcation and fold spaces. PART 3 - TOPOLOGY: Folds, tangles and knots. Structure prediction and modelling. PART 4 - SYMMETRY: Structural symmetry. Evolution and Origins. References. Index.

O autorze

Taylor, William R.; Aszodi, Andras