Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an...
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulat...
The adaptive immune system ensures that our bodies remember pathogens so that we can rapidly mount an immune response if they are encountered again, without succumbing to infection. This volume examines the basis of this immune memory and the roles of the T and B cells involved. Topics covered in this essential volume include: - Do memory CD4 T cells keep their cell type programming: Plasticity versus fate commitment? - Is it possible to develop a "universal" influenza vaccine? - What is the value of animal models in predicting vaccine efficacy in humans? - Is a human CD8 T...
The adaptive immune system ensures that our bodies remember pathogens so that we can rapidly mount an immune response if they are encountered again, w...
Prostate cancer is the second most common type of cancer and affects millions of individuals worldwide. This volume reviews our understanding of the disease, its progression, and new therapeutic approaches. Topics include: -Anatomy and Histology of the Human and Murine Prostate -Prostate Cancer Genetics -Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood -Stem Cells and Cancer Stem Cells -Epigenetics -New Opportunities for Targeting the Androgen Receptor in Prostate Cancer -Chemoprevention in...
Prostate cancer is the second most common type of cancer and affects millions of individuals worldwide. This volume reviews our understanding of the d...
Complexes that link neighboring cells play a critical role maintaining tissue integrity and allowing cells to communicate and remodel. This volume discusses structure and function of cell junctions and the roles they play in development and cancer.
Complexes that link neighboring cells play a critical role maintaining tissue integrity and allowing cells to communicate and remodel. This volume dis...