Immune Memory and Vaccines: Great Debates

ISBN-13: 9781621821540 / Angielski / Twarda / 2018 / 432 str.

Shane Crotty; Rafi Ahmed

Opis

The adaptive immune system ensures that our bodies remember pathogens so that we can rapidly mount an immune response if they are encountered again, without succumbing to infection. This volume examines the basis of this immune memory and the roles of the T and B cells involved.

Topics covered in this essential volume include:
- Do memory CD4 T cells keep their cell type programming: Plasticity versus fate commitment?
- Is it possible to develop a "universal" influenza vaccine?
- What is the value of animal models in predicting vaccine efficacy in humans?
- Is a human CD8 T cell vaccine possible? If so, what would it take?
- Is it possible to develop cancer vaccines to neo-antigens? What are the major challenges and how can these be overcome?
- What are the most powerful immunogen design vaccine strategies?