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The Renal Circulation: Volume 9
ISBN: 9780762306176 / Angielski / Twarda / 428 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
cena:
621,32 |
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Reflections on a Theory of Organisms: Holism in Biology
ISBN: 9780801859700 / Angielski / Miękka / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Are living organisms--as Descartes argued--just machines? Or is the nature of life such that it can never be fully explained by mechanistic models? In this thought-provoking and controversial book, eminent geophysicist Walter M. Elsasser argues that the behavior of living organisms cannot be reduced to physico-chemical causality. Suggesting that molecular biology today is at the same point as Newtonian physics on the eve of the quantum revolution, Elsasser lays the foundation for a theoretical biology that points the way toward a natural philosophy of organic life. Explicitly... Are living organisms--as Descartes argued--just machines? Or is the nature of life such that it can never be fully explained by mechanistic models?... |
cena:
117,62 |
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Assembly of the Vasculature and Its Regulation
ISBN: 9780817642297 / Angielski / Twarda / 279 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis...
The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lin...
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cena:
534,05 |
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Genetics of Bacterial Polysaccharides
ISBN: 9780849300219 / Angielski / Twarda / 256 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Bacterial surface or secreted polysaccharides are molecules that can function as barriers to protect bacterial cells against environmental stresses, as well as act as adhesins or recognition molecules. In some cases, these molecules are immunodominant antigens eliciting a vigorous immune response, while in other cases the expression of polysaccharides camouflages the bacteria from the immune system. Until recently, most studies on the enzymatic steps and regulation of these molecules were performed on the enteric gram negative bacteria Escherichia coli and Salmonella typhimurium. With the...
Bacterial surface or secreted polysaccharides are molecules that can function as barriers to protect bacterial cells against environmental stresses, a...
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cena:
1357,85 |
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Molecular Biology of the Biological Control of Pests and Diseases of Plants
ISBN: 9780849324420 / Angielski / Twarda / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. While many books are available on biological control, this is the only book to detail the application of molecular biology to control of pests and diseases. Each chapter deals with a different pathogen and the application of new molecular biological techniques to the biocontrol of the pathogen.
This new reference presents the most comprehensive list of organisms available. Internationally respected experts discuss viruses, bacteria, fungi, nematodes, protozoa, weeds, and insects. Types of control methods are described, and techniques commonly used in molecular biology to identify the... While many books are available on biological control, this is the only book to detail the application of molecular biology to control of pests and dis...
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cena:
1555,35 |
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Immunogold-Silver Staining: Principles, Methods, and Applications
ISBN: 9780849324499 / Angielski / Twarda / 304 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book discusses the principles, methods, and applications of immunogold-silver staining (IGSS) to biomedical areas. It focuses on the latest advances in the dynamic and progressive field of IGSS.
This book discusses the principles, methods, and applications of immunogold-silver staining (IGSS) to biomedical areas. It focuses on the latest advan...
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cena:
617,20 |
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Analytical Molecular Biology: Quality and Validation
ISBN: 9780854044726 / Angielski / Miękka / 208 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In spite of the wide variety and complexity of biological materials, nucleic acids are ubiquitous. DNA is becoming the bioanalyte of choice due to the vast amount of information embedded in its sequence, its robust chemical nature and the range of highly sensitive analytical techniques that have been developed. The results of such analyses can have an important impact on our society both commercially and in terms of the quality of life. Absolute confidence in the data generated is therefore of the utmost importance. This book, produced by LGC as part of the VAM (Valid Analytical Measurement)...
In spite of the wide variety and complexity of biological materials, nucleic acids are ubiquitous. DNA is becoming the bioanalyte of choice due to the...
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cena:
419,45 |
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Single-Molecule Techniques: A Laboratory Manual
ISBN: 9780879697754 / Angielski / Miękka / 507 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. As molecular and cellular biologists move toward nanotechniques for performing experiments on single molecules rather than on populations of molecules, a comprehensive manual on how (and why) to carry out such experiments is needed. Single-Molecule Techniques: A Laboratory Manual fills this requirementit is the first to take researchers who know nothing about singlemolecule analyses to the point where they can successfully design and execute appropriate experiments. Geared toward research scientists in structural and molecular biology, biochemistry, and biophysics, the manual will be useful...
As molecular and cellular biologists move toward nanotechniques for performing experiments on single molecules rather than on populations of molecules...
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cena:
617,04 |
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Retinoid Protocols
ISBN: 9780896034389 / Angielski / Twarda / 434 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Interest in retinoic acid, the main biologically active derivative of vi- min A or retinol, increased dramatically between 1989 and 1993, following the cloning of nuclear receptors or RARs reported in 1987 (Fig. 1). Important discoveries since then have shown how RARs work as all-trans retinoic ac- dependent heterodimers with related nuclear receptors for 9-cis retinoic acid called RXRs. This has stimulated the development of synthetic analogs s- cific for each type of receptor, and opens the way to develop new methods for regulating pharmacologically the activity ofretinoic acid-dependent...
Interest in retinoic acid, the main biologically active derivative of vi- min A or retinol, increased dramatically between 1989 and 1993, following th...
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cena:
825,37 |
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Protein Phosphatase Protocols
ISBN: 9780896034686 / Angielski / Twarda / 316 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A major mechanism by which cells regulate protein function is to place phosphate groups on serine and threonine residues. Though the steady-state level of protein phosphorylation depends on the relative activities of both kinases and phosphatases, a much greater effort has previously gone into the study of the former that the latter . Today, however, there is an increasing appreciation for the role that protein phosphatases play in the dynamic p- cess of protein phosphorylation . To date, there are four major types of protein serine/threonine phosphatase catalytic subunits, designated protein...
A major mechanism by which cells regulate protein function is to place phosphate groups on serine and threonine residues. Though the steady-state leve...
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cena:
534,05 |
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PCR in Bioanalysis
ISBN: 9780896034976 / Angielski / Twarda / 281 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Offers powerful PCR-based protocols and assays in actual use or potential use in clinical medicine and commercial biology. The main focus of the book is on the commercial applications of PCR, as opposed to basic research uses. Topics covered include: the measurement of hormone levels using PCR; transcription factor isolation; detection of viruses using PCR; detection of tumour contamination of stem cells; and evaluation of grafts for tumour cells.
Offers powerful PCR-based protocols and assays in actual use or potential use in clinical medicine and commercial biology. The main focus of the book ...
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cena:
405,36 |
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2-D Proteome Analysis Protocols
ISBN: 9780896035249 / Angielski / Twarda / 601 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. With the completion of sequencing projects and the advancement of a- lytical tools for protein identification, proteomics the study of the expressed part of the genome has become a major region of the burgeoning field of functional genomics. High-resolution 2-D gels can reveal virtually all p- teins present in a cell or tissue at any given time, including posttranslationally modified proteins. Changes in the expression and structure of most cellular proteins caused by differentiation or external stimuli can be displayed and eventually identified using 2-D protein gels. 2-D Proteome Analysis...
With the completion of sequencing projects and the advancement of a- lytical tools for protein identification, proteomics the study of the expressed p...
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cena:
608,07 |
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Protein Lipidation Protocols
ISBN: 9780896035348 / Angielski / Twarda / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. It is hard to think of a protein in eukaryotic cells that does not undergo some type of posttranslational modification. The covalent attachment of l- ids to proteins, protein lipidation, occurs for a few thousand proteins. Several functions for protein lipidation are known. Protein lipids may target proteins to specific cellular membranes, they may serve as molecular switches that allow cytosol-to-membrane transfer, they may direct protein-protein compl- ation, and they may stabilize protein structure. In cases such as the fatty a- lation of intracellular loops of transmembrane proteins, the...
It is hard to think of a protein in eukaryotic cells that does not undergo some type of posttranslational modification. The covalent attachment of l- ...
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cena:
608,07 |
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Stress Response: Methods and Protocols
ISBN: 9780896036116 / Angielski / Twarda / 488 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a...
Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents p...
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cena:
534,05 |
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Genomic Imprinting: Methods and Protocols
ISBN: 9780896037410 / Angielski / Twarda / 377 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy...
Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally in...
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cena:
405,36 |
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Steroid Receptor Methods: Protocols and Assays
ISBN: 9780896037540 / Angielski / Twarda / 381 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume of the Methods in Molecular Biology series is entirely devoted to the study of steroid receptor biology. Steroid hormone receptors represent a powerful system for the study of both the most fundamental molecular mec- nisms of gene regulation and control and the gross physiological responses of organisms to steroid hormones. Research in this field has brought forth advances in the treatment of cancer, endocrine disorders, and reproductive biology, and allowed elucidation of the fundamental biological mechanisms of gene expr- sion. In Steroid Receptor Methods: Protocols and Assays,...
This volume of the Methods in Molecular Biology series is entirely devoted to the study of steroid receptor biology. Steroid hormone receptors represe...
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cena:
534,05 |
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DNA Arrays: Methods and Protocols
ISBN: 9780896038226 / Angielski / Twarda / 264 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Microarray technology provides a highly sensitive and precise te- nique for obtaining information from biological samples, with the added advantage that it can handle a large number of samples simultaneously that may be analyzed rapidly. Researchers are applying microarray technology to understand gene expression, mutation analysis, and the sequencing of genes. Although this technology has been experimental, and thus has been through feasibility studies, it has just recently entered into widespread use for advanced research. The purpose of DNA Arrays: Methods and Protocols is to provide...
Microarray technology provides a highly sensitive and precise te- nique for obtaining information from biological samples, with the added advantage th...
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cena:
534,05 |
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Two-Hybrid Systems
ISBN: 9780896038325 / Angielski / Twarda / 336 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Many, if not all, essential biological processes require selective interactions between proteins. Complex signaling systems require sequential, ordered protein-protein interactions at essentially all levels of the signaling cascade. For example, peptide hormones interact with selective membrane receptor proteins, and autophosphorylation of the receptor then recruits other key regulatory proteins that initiate kinase cascades in which each phosphorylation event requires selective recognition of the protein substrate. The ultimate signaling effect, in many cases, is the regulation of RNA...
Many, if not all, essential biological processes require selective interactions between proteins. Complex signaling systems require sequential, ordere...
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cena:
534,05 |
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Biostatistical Methods
ISBN: 9780896039513 / Angielski / Twarda / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading biostatisticians and biomedical researchers describe many of the key techniques used to solve commonly occurring data analytic problems in molecular biology, and demonstrate how these methods can be used in the development of new markers for exposure to a risk factor or for disease outcomes. Major areas of application include microarray analysis, proteomic studies, image quantitation, genetic susceptibility and association, evaluation of new biomarkers, and power analysis and sample size.
Leading biostatisticians and biomedical researchers describe many of the key techniques used to solve commonly occurring data analytic problems in mol...
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cena:
405,36 |
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Thyroid Hormone Receptors: Methods and Protocols
ISBN: 9780896039957 / Angielski / Twarda / 223 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying...
A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their pr...
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cena:
534,05 |
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