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DNA Replication and Human Disease
ISBN: 9780879697662 / Angielski / Twarda / 814 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of...
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trill...
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cena:
533,04 zł |
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Gene Targeting Protocols
ISBN: 9780896033603 / Angielski / Twarda / 233 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- cess has emerged primarily from two sources: (1) The principles of reaction mechanics have come from detailed biochemical analyses of the RecA protein...
The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situ...
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cena:
583,65 zł |
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Gene Knockout Protocols
ISBN: 9780896035720 / Angielski / Twarda / 431 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. As the major task of sequencing the human genome is near completion and full complement of human genes are catalogued, attention will be focused on the ultimate goal: to understand the normal biological functions of these genes, and how alterations lead to disease states. In this task there is a severe limitation in working with human material, but the mouse has been adopted as the favored animal model because of the available genetic resources and the highly conserved gene conservation linkage organization. In just of ten years since the first gene-targeting experiments were p- formed in...
As the major task of sequencing the human genome is near completion and full complement of human genes are catalogued, attention will be focused on th...
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cena:
389,09 zł |
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Transcription Factor Protocols
ISBN: 9780896035737 / Angielski / Twarda / 306 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal...
The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasi...
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cena:
389,09 zł |
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DNA Sequencing Protocols
ISBN: 9780896037212 / Angielski / Miękka / 256 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Colin Graham and a team of leading investigators and expert clinical scientists update the acclaimed first edition with a collection of powerful, up-to-date PCR-based methods for DNA sequencing, many suitable for human genome sequencing and mutation detection in human disease. This second edition offers new material on automated DNA sequencers, capillary DNA sequencers, heterozygote mutation detection, web-based sequencing databases and genome sequencing sites, and the human genome project. State-of-the-art and highly practical, DNA Sequencing Protocols, 2nd Edn. constitutes an essential...
Colin Graham and a team of leading investigators and expert clinical scientists update the acclaimed first edition with a collection of powerful, up-t...
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cena:
389,09 zł |
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Quantitative Trait Loci: Methods and Protocols
ISBN: 9780896039278 / Angielski / Twarda / 360 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to...
In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to ...
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cena:
583,65 zł |
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In Situ Detection of DNA Damage: Methods and Protocols
ISBN: 9780896039520 / Angielski / Twarda / 313 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion, carcinogenesis, tumor growth, embryogenesis and aging, neu- degenerative and heart diseases, anticancer drug development, environmental and radiobiological research, and others. Individual cells within the same tissue or in cell culture may vary in the extent of their DNA damage and, consequently, can display different re- tions to it. These differences between individual cells in the same cell popu- tion are detected using in situ approaches....
Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion...
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cena:
389,09 zł |
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Bacterial Artificial Chromosomes: Volume 1: Library Construction, Physical Mapping, and Sequencing
ISBN: 9780896039889 / Angielski / Twarda / 360 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. For both volumes: Expert investigators describe not only the classic methods, but also the many novel techniques they have perfected for the transfer of large DNAs into the cells of both microbes and animals via large-insert recombinant DNAs. Volume 1 presents readily reproducible techniques for library construction, physical mapping, and sequencing.. An accompanying volume, Volume 2: Functional Studies, provides a wide variety of methods and applications for functional analysis of the DNA-transformed organisms. Besides protocols, each chapter includes scientific reviews, software tools,...
For both volumes: Expert investigators describe not only the classic methods, but also the many novel techniques they have perfected for the tran...
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cena:
389,09 zł |
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Bacterial Artificial Chromosomes: Volume 2: Functional Studies
ISBN: 9780896039896 / Angielski / Twarda / 326 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Several developmental and historical threads are woven and displayed in these two volumes of Bacterial Artificial Chromosomes, the first on Library Construction, Physical Mapping, and Sequencing, and the second on Fu- tional Studies. The use of large-insert clone libraries is the unifying feature, with many diverse contributions. The editors have had quite distinct roles. Shaying Zhao has managed several BAC end-sequencing projects. Marvin Stodolsky during 1970 1980 contributed to the elucidation of the natural b- teriophage/prophage P1 vector system. Later, he became a member of the Genome...
Several developmental and historical threads are woven and displayed in these two volumes of Bacterial Artificial Chromosomes, the first on Library Co...
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cena:
389,09 zł |
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Why I'm Like Dad
ISBN: 9780898751420 / Angielski / Miękka / 268 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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56,56 zł |
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Heredity and Its Variability
ISBN: 9780898756609 / Angielski / Miękka / 140 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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87,80 zł |
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Exploring Genetic Mechanisms
ISBN: 9780935702705 / Angielski / Twarda / 674 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This collaborative work should be of interest to students and professionals in the field of biochemistry, molecular biology and genetics. The book discusses efforts to map and sequence the genomes of several species, including humans, and illustrates the depth of understanding now provided by state-of-the-art techniques in molecular biology, biochemistry and genetics. The case studies examine in detail how genes operate in complex, multicomponent and interacting systems, applying these studies to a variety of living systems including viral, cellular, and organismal models. How genotypes and...
This collaborative work should be of interest to students and professionals in the field of biochemistry, molecular biology and genetics. The book dis...
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cena:
437,64 zł |
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Essays on Genetic Evolution and Economics
ISBN: 9780965856423 / Angielski / Miękka / 164 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
cena:
115,62 zł |
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Atlas of Human Chromosome Heteromorphisms
ISBN: 9781402013034 / Angielski / Twarda / 279 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Critical to the accurate diagnosis of human illness is the need to distinguish clinical features that fall within the normal range from those that do not. That distinction is often challenging and not infrequently requires considerable experience at the bedside. It is not surprising that accurate cytogenetic diagnosis is also often a challenge, especially when chromosome study reveals morphologic findings that raise the question of normality. Given the realization that modern human cytogenetics is just over five decades old, it is noteworthy that thorough documentation of normal chromosome...
Critical to the accurate diagnosis of human illness is the need to distinguish clinical features that fall within the normal range from those that do ...
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cena:
1167,35 zł |
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Genetics and Ethics in Global Perspective
ISBN: 9781402017681 / Angielski / Twarda / 474 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Dorothy Wertz and John Fletcher pioneered the first international study of ethical and social issues in genetics in 18 nations. This book reports and discusses their second and more representative study in 36 nations. The survey focused on actual situations that occur in the practice of medical genetics, presented as case vignettes that can also be used in teaching and policy discussion. Among the issues discussed are privacy, prenatal diagnosis, patient autonomy, directiveness in counseling, sex selection, forensic DNA banking, "genetic discrimination," and "eugenics." Dorothy Wertz and John Fletcher pioneered the first international study of ethical and social issues in genetics in 18 nations. This book reports a... |
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583,65 zł |
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Radiation Risk Estimates in Normal and Emergency Situations
ISBN: 9781402049545 / Angielski / Twarda / 373 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In September 2005, Yerevan (Armenia) hosted an International Conference dedicated to the 70th anniversary of the publication of the so called "green paper," published by N.W. Timofeeff-Ressovsky, K. Zimmer and M. Delbruck in 1935, entitled "On the origin of gene mutations and gene structure." The importance of this paper for genetics and radiobiology was enormous not only for radiobiology, but for genetics in general. The "target" of the radiation action was indeed the "gene," that for the first time found a clear, operational definition. The organisers of this Conference proposed to... In September 2005, Yerevan (Armenia) hosted an International Conference dedicated to the 70th anniversary of the publication of the so called "gree... |
cena:
583,65 zł |
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Genetics in Liver Disease
ISBN: 9781402063923 / Angielski / Twarda / 180 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Articles represent the proceedings of the Falk Symposium No. 156 on Genetics in Liver Disease, part of the XIII International Liver Week 2006 held in Freiburg, Germany. Contributions come from an international team of leading scientists and clinicians. In the tradition of the Falk Symposia, this book provides an exciting overview of current developments in the genetics of liver diseases, their diagnosis, treatment, and prevention. Articles represent the proceedings of the Falk Symposium No. 156 on Genetics in Liver Disease, part of the XIII International Liver Week 2006 held ... |
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583,65 zł |
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A Practical Approach to Microarray Data Analysis
ISBN: 9781402072604 / Angielski / Twarda / 368 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the...
In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its abil...
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cena:
194,52 zł |
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Methods of Microarray Data Analysis III: Papers from Camda '02
ISBN: 9781402075827 / Angielski / Twarda / 252 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. As microarray technology has matured, data analysis methods have advanced as well. Methods Of Microarray Data Analysis III is the third book in this pioneering series dedicated to the existing new field of microarrays. While initial techniques focused on classification exercises (volume I of this series), and later on pattern extraction (volume II of this series), this volume focuses on data quality issues. Problems such as background noise determination, analysis of variance, and errors in data handling are highlighted. Three tutorial papers are presented to... As microarray technology has matured, data analysis methods have advanced as well. Methods Of Microarray Data Analysis III is the ... |
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194,52 zł |
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Principles of Genome Analysis and Genomics
ISBN: 9781405101202 / Angielski / Miękka / 288 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. With the first draft of the human genome project in the public domain and full analyses of model genomes now available, the subject matter of 'Principles of Genome Analysis and Genomics' is even 'hotter' now than when the first two editions were published in 1995 and 1998. In the new edition of this very practical guide to the different techniques and theory behind genomes and genome analysis, Sandy Primrose and new author Richard Twyman provide a fresh look at this topic. In the light of recent exciting advancements in the field, the authors have completely revised and rewritten many parts...
With the first draft of the human genome project in the public domain and full analyses of model genomes now available, the subject matter of 'Princip...
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cena:
366,25 zł |
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