Kategoria BISAC: Science >> Life Sciences - Biology

From the Foreword:

-This book exemplifies one of the most successful approaches to modeling and simulating the] new generation of complex systems. FLAME was designed to make the building of large scale complex systems models straightforward and the simulation code that it generates is highly efficient and can be run on any modern technology. FLAME was the first such platform that ran efficiently on high performance parallel computers and a version for GPU technology is also available. At its heart, and the reason why it is so efficient and robust, is the use of a...

The uses of nucleic acid-directed methods have increased significantly in the past five years and have made important contributions to disease control country programmes for improving national and international trade. These developments include the more routine use of PCR as a diagnostic tool in veterinary diagnostic laboratories. There are, however, many problems associated with the transfer and particularly the application of this technology. These include a lack of consideration for the implementation and establishment of quality-assured procedures, the required set-up of the laboratory...

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large...

There have been tremendous advancements in application of modeling and simulation (M&S) in drug development during the last decade. The pharmaceutical companies started to pay more attention to implement simulation exercises in drug development in order to achieve cost effectiveness. The Food and Drug Administration (FDA) published a white paper titled, Critical Path Initiatives, in March 2004. This puts forward model based drug development that calls for use of quantitative M&S to facilitate informed decisions. The European Medicines Agency (EMEA) also encourages use of simulations in...

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim,...

Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents.
Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and...