Kategoria BISAC: Nature >> Animals - Mammals

Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against...

Circadian rhythms are such an innate part of our lives that we rarely pause to speculate why they even exist. Some studies have suggested that the disruption of the circadian system may be causal for obesity and manifestations of Metabolic Syndrome (MetS). Shift-work, sleep-deprivation and bright-light-exposure at night are related to increased adiposity (obesity) and prevalence of MetS. It has been provided evidence of clock genes expression in human adipose tissue and demonstrated its association with different components of the MetS. Moreover, current studies are illustrating the...

Originally published in 1914 by the Tribune Press, Wolf Days in Pennsylvania preserves the fascinating history of Pennsylvania's lost wolves and their hunters, which was already becoming the stuff of folklore and myth during Shoemaker's lifetime at the turn of the twentieth century. With his characteristic penchant for juicy narrative and a naturalist's enthusiasm and respect for the animal, Shoemaker details the decline of the wolf in Pennsylvania during the westward progress of the state's settlement by whites, as its population dwindled over the course of the nineteenth...

Durch neuartige und verbesserte Methoden zur molekulargenetischen Diagnostik kommt es immer haufiger zum Problem der genetischen Zufallsbefunde (oder besser: Zusatzbefunde). Darunter versteht man Befunde oder Auffalligkeiten, die unabhangig von der ursprunglichen medizinischen Fragestellung oder aus wissenschaftlichen Studien heraus entstehen, jedoch Bedeutung fur die Gesundheit und Familienplanung der untersuchten Person sowie ihrer leiblichen Verwandten haben konnen.

Die Beitrage des Buches entstammen einer vom Bundeministerium fur Bildung und Forschung geforderten Fachtagung an...

This book covers recent developments and possible pitfalls in the diagnosis of genetic movement disorders and related conditions. It is divided into three sections: technical and scientific aspects; clinical aspects with guidance towards work-up; and ethical and legal aspects of genetic testing in a clinical and research setting.

The first section includes chapters on genetic analysis and counselling with critical discussion of potential problems when interpreting the results. Clinical chapters summarize genetic forms of movement disorders including parkinsonism, tics and dystonia...

Covering the behavior and ecology of the northern fur seal, this book is a model long-term study of marine mammals, one that tests theory through both observation of undisturbed behavior and manipulative experiments on individuals. Here Roger Gentry draws on nearly two decades of research on three different islands to show how behavior among these seals changes with population size, sex ratio, and environment, to explain the behavior of the population beginning with individuals, and to generalize the results to other members of the eared seal family. In so doing, he offers one of the most...

Alaska is truly bear country. It is the only one of America s fifty states to be inhabited by all three of North America s ursine species: black, polar bear, and brown bear (also known as grizzly). Alaska s Bears is a handy guidebook to the bears of Alaska, a book that slips easily into a jacket pocket or a day pack, and that provides entertaining armchair reading when you re not in bear country.

Here in one compact edition is a book that can help you understand Alaska s bears and their natural histories. Learn about their appearances, behaviors, yearly cycles, ecological...