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Serotonin and Gastrointestinal Function
ISBN: 9780849383878 / Angielski / Twarda / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues. This book covers neurochemistry, physiology, pharmacology, and clinical issues relevant to serotonin in the gastrointestinal tract. The editors have brought together the most relevant information from the molecular to the clinical level. Each chapter is written by investigators experienced in research on serotonin's actions in the gut. This book will be useful to basic scientists, clinical investigators, graduate and postgraduate...
Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointes...
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cena:
1700,24 |
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Principles of Cardiac Toxicology
ISBN: 9780849388095 / Angielski / Twarda / 704 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. What chemicals are poisonous to the heart and why are they toxic? Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce toxicity by interacting with elements of the cardiovascular system. This book presents the anatomical, physiological, biochemical, and pathological basis for this interaction and describes the classes of chemicals known to produce cardiovascular toxicity. Characteristics of potential antidotes are also discussed. Clinicians and researchers will discover that this volume is an essential guide to understanding factors that could contribute to...
What chemicals are poisonous to the heart and why are they toxic? Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce ...
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cena:
874,41 |
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Copper and the Skin
ISBN: 9780849395321 / Angielski / Twarda / 328 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of conditions including skin irritation, sensitization, rheumatoid arthritis, and other inflammatory conditions. This source reviews general principles of percutaneous penetration to clarify the mechanisms controlling anti-inflammatory activity, dermal sensitivity, and the absorption of copper compounds in the human body and the effects of these functions on healthy skin and human health.
Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of condition...
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cena:
1020,15 |
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Animal Models of Diabetes: Frontiers in Research
ISBN: 9780849395345 / Angielski / Twarda / 384 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This new edition of Animal Models of Diabetes provides researchers with updated and expanded information regarding the use models in experiments with both Type 1 and Type 2 diabetes. It compiles relevant timesaving information on most, if not all, current well-recognized models for both types of diabetes, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. Among several other topics, it discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. It also addresses the importance of...
This new edition of Animal Models of Diabetes provides researchers with updated and expanded information regarding the use models in experiments with ...
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cena:
1068,72 |
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A Practical Guide to Quality Management in Clinical Trial Research
ISBN: 9780849397226 / Angielski / Twarda / 232 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Setting up a GXP environment where none existed previously is a very daunting task. Getting staff to write down what they do for every task is a correspondingly difficult and time-consuming exercise. Examining how to maintain quality control in clinical trial research, A Practical Guide to Quality Management in Clinical Trial Research provides a cornerstone of knowledge for establishing a quality system that complies with the relevant regulations. There are many books available that cover how to interpret regulations. Going a step or two further, this book provides practical advice that is...
Setting up a GXP environment where none existed previously is a very daunting task. Getting staff to write down what they do for every task is a corre...
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cena:
922,99 |
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Pharmaceutical Calculations Workbook
ISBN: 9780853696025 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Pharmaceutical Calculations Workbook is the companion self-study aid to Introduction to Pharmaceutical Calculations, 2E. It contains practice calculations (with answers) similar to those that might be presented in pharmacy examinations and in practice. Each chapter contains a variety of exercises for practicing calculations using the methods covered in the companion text. Tables for completion are included in addition to individual drug- or patient-specific, questions.
Pharmaceutical Calculations Workbook is the companion self-study aid to Introduction to Pharmaceutical Calculations, 2E. It contains practice calculat...
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cena:
131,17 |
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Alternatives to Animal Testing
ISBN: 9780854042111 / Angielski / Twarda / 136 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to...
Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more exp...
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cena:
291,23 |
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DNA Topoisomerase Protocols: Volume II: Enzymology and Drugs
ISBN: 9780896035126 / Angielski / Twarda / 334 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Beginning with the Escherichia coli ? protein, or bacterial DNA topoisomerase I, an ever-increasing number of enzymes have been identified that catalyze changes in the linkage of DNA strands. DNA topoisomerases are ubiquitous in nature and have been shown to play critical roles in most p- cesses involving DNA, including DNA replication, transcription, and rec- bination. These enzymes further constitute the cellular targets of a number of clinically important antibacterial and anticancer agents. Thus, further studies of DNA topology and DNA topoisomerases are critical to advance our und-...
Beginning with the Escherichia coli ? protein, or bacterial DNA topoisomerase I, an ever-increasing number of enzymes have been identified that cataly...
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cena:
402,53 |
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Drug Development: Molecular Targets for GI Diseases
ISBN: 9780896035898 / Angielski / Twarda / 278 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The application of molecular techniques to gastroenterology continues to yield important advances in the development of drugs to treat gastrointestinal disorders. Important new drugs have emerged through the collaborative and complementary efforts of basic scientists, clinicians, and clinical researchers in academia and the pharmaceutical industry. The challenge has been exciting, with a few surprises along the way. Consider peptic ulcer disease as an example. The discovery of H receptors and the availability of potent and 2 selective H-receptor antagonists signaled the beginning of a new era...
The application of molecular techniques to gastroenterology continues to yield important advances in the development of drugs to treat gastrointestina...
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cena:
402,53 |
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Platinum-Based Drugs in Cancer Therapy
ISBN: 9780896035997 / Angielski / Twarda / 341 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the...
Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining...
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cena:
603,81 |
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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery: Electrically Mediated Delivery of Molecules to Cells
ISBN: 9780896036062 / Angielski / Twarda / 497 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Pulsed electric fields have been applied to living systems in vitro for a host of delivery applications since the early 1980s. It has been established that the primary effect that electrical treatment has on cells is an induced increase in the permeability of membranes to exogenous molecules. This state of increased permeability was noted to be temporary and could be induced with little or no effect on cell viability. This physical phenomenon was termed electroporation. Numerous published studies have shown that electroporation can be applied to any cell type. These studies also exploited the...
Pulsed electric fields have been applied to living systems in vitro for a host of delivery applications since the early 1980s. It has been established...
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cena:
603,81 |
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Regional Chemotherapy: Clinical Research and Practice
ISBN: 9780896037298 / Angielski / Twarda / 366 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas...
Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antine...
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cena:
603,81 |
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Immunotoxin Methods and Protocols
ISBN: 9780896037755 / Angielski / Twarda / 297 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized since they were first conceived of by Paul Ehrlich in 1906. The majority of advances in the development and implementation of immunotoxins has occurred over the last 20 years. The reasons for this use of immunotoxins in basic science and clinical research are the powerful concurrent advances in genetic engineering and receptor physiology. Recombinant technology has allowed investigators to produce sufficient quantities of a homogeneous c- pound that...
Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized sinc...
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cena:
402,53 |
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Drug Delivery Systems in Cancer Therapy
ISBN: 9780896038882 / Angielski / Twarda / 390 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have...
Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors re...
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cena:
805,10 |
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Immunosuppressant Analogs in Neuroprotection
ISBN: 9780896039445 / Angielski / Twarda / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents." The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory...
An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from ...
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cena:
603,81 |
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Benzodiazepines and Ghb: Detection and Pharmacology
ISBN: 9780896039810 / Angielski / Twarda / 148 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol(r) and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today's...
Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective me...
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cena:
603,81 |
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Oncogene-Directed Therapies
ISBN: 9780896039827 / Angielski / Twarda / 487 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic...
Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clin...
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cena:
603,81 |
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Organ Directed Toxicities of Anticancer Drugs: Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Dru
ISBN: 9780898383560 / Angielski / Twarda / 254 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif- ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in- tervention. Much of this toxicity, such as damage to the bone marrow, gastroin- testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively...
The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability t...
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cena:
603,81 |
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Principles of Radiopharmacology
ISBN: 9780898387742 / Angielski / Twarda / 260 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This publication contains a collection of 22 manuscripts by authors invited to write review articles. They are based on lectures presented on the First and Second Training Course in Radiopharmacy and Radiopharmacology. These courses were organized under the auspices of the "Joint Committee on Radiopharmaceuticals" of both European Societies of Nuclear Medicine (ENMS and SNME) and were sponsored by the European Society of Nuclear Medicine (ENMS). Recent developments in radiopharmacy and radiopharmacology have been very complex; they cannot be overlooked by the medical staff in nuclear medical...
This publication contains a collection of 22 manuscripts by authors invited to write review articles. They are based on lectures presented on the Firs...
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cena:
603,81 |
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Progress in Radiopharmacy
ISBN: 9780898388237 / Angielski / Twarda / 616 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was held in St. Catharine's College Cambridge in March 1985. This meeting was organized by the Radiopharmacy Group of the British Nuclear Medicine Society under the auspices of the European Joint Committee on Radio pharmaceuticals of the ENMS / SNME. The Joint Committee acknowledges the special effort which was made by the local organizers to prepare this meeting the quality of which is undoubtedly reflected in the proceedings. The wide ranging aspects...
The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was hel...
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cena:
1811,52 |
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