Animal Models of Diabetes: Frontiers in Research

ISBN-13: 9780849395345 / Angielski / Twarda / 2007 / 384 str.

Eleazar Shafrir

Opis

This new edition of Animal Models of Diabetes provides researchers with updated and expanded information regarding the use models in experiments with both Type 1 and Type 2 diabetes. It compiles relevant timesaving information on most, if not all, current well-recognized models for both types of diabetes, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. Among several other topics, it discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. It also addresses the importance of recent findings on pathogenesis of diabetes and its complications in relation to human disease.

Spis treści

Autoimmune diabetes, present status of knowledge in animals and the implications for the understanding and preventing of human type 1 diabetes. Diabesity in ob/ob and db/db mice: the use of these models for studies of diabetes and obesity in humans. The Zucker diabetic fatty rat: lessons from leptin receptor deficiency. The Goto-Kaizaki diabetic rat evolved by selective inbreeding. Then NSY mouse, an animal model with human type 2 diabetes with polygenic inheritance. The new Zealand obese mouse, a polygenic model of type 2 diabetes, metabolic abnormalities without single genetic mutation. The OLETF rat, spontaneous interaction of diabetes and obesity and the associated nephropathy. The JCR: Lacp rat a model of obesity, insulin resistance, and atherosclerosis cardiovascular disease. The neonatally sterptozotocin induced diabetic rat: a family of type 2 diabetes like animal models. The rhesus monkey (Macaca Mulatta) a model for the study of gradual development of diabetes on ad libitum nutrition. The desert gerbil, Psammomys obesus: molecular mechanisms of the nutritionally induced diabetes, and its prevention; validity for study of factors underlying the prevalent diabetes epidemic, related to affluent nutrition. The C57BL6J mouse, a model of diet induced type 2 diabetes, hypertension, and obesity. The obese, spontaneously hypertensive SHROB, Koletzky rat: a model for human metabolic syndrome. The diabetic minipig, sharing physiologic and digestion characteristics with the human. The spontaneously diabetic Torii (SDT) rat with human resembling retinopathy lesions.

O autorze

Eleazar Shafrir