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Protein Misfolding and Disease
ISBN: 9781617373329 / Angielski / Miękka / 318 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of...
For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation ...
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576,96 zł |
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Molecular Cytogenetics: Protocols and Applications
ISBN: 9781617373008 / Angielski / Miękka / 414 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The new techniques of molecular cytogenetics, mainly fluorescence in situ hybridization (FISH) of DNA probes to metaphase chromosomes or interphase nuclei, have been developed in the past two decades. Many FISH techniques have been implemented for diagnostic services, whereas some others are mainly used for investigational purposes. Several hundreds of FISH probes and hybridization kits are now commercially available, and the list is growing rapidly. FISH has been widely used as a powerful diagnostic tool in many areas of medicine including pediatrics, medical genetics, maternal fetal...
The new techniques of molecular cytogenetics, mainly fluorescence in situ hybridization (FISH) of DNA probes to metaphase chromosomes or interphase nu...
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576,96 zł |
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Epithelial Cell Culture Protocols
ISBN: 9781617372414 / Angielski / Miękka / 406 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. There have been significant advances in research involving the isolation and culture of epithelial cells in the past decade, and many new techniques have been developed. Monolayer cultures can be used to evaluate the nature and behavior of cells, while the use of epithelial cells in model systems has allowed a deeper understanding of cellular and molecular mechanisms and interactions. The aim of this book is to provide a comprehensive, step-by-step guide to many techniques for epithelial cell culture, combining in one volume the more commonly used protocols along with many that are more...
There have been significant advances in research involving the isolation and culture of epithelial cells in the past decade, and many new techniques h...
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499,87 zł |
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The G Protein-Coupled Receptors Handbook
ISBN: 9781617375224 / Angielski / Miękka / 412 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also...
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of G...
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769,29 zł |
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Olivocerebellar Projection: A Review
ISBN: 9783540103059 / Angielski / Miękka / 140 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In recent years the inferior olive and its projection to the cerebellum have attracted considerable interest. Numerous experimental anatomic and electrophysiologic studies have been undertaken, and much new information has been brought forward. Many apparently discordant observations have been reported however, and on many points the data obtained by the use of different methbds and approaches appear to be diffi- cult to reconcile. Much of the interest in the olivocerebellar projection concerns the topographical localization within the projection. Particularly as a result of research in...
In recent years the inferior olive and its projection to the cerebellum have attracted considerable interest. Numerous experimental anatomic and elect...
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384,63 zł |
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Seasonal Spermatogenesis in the Mute Swan (Cygnus Olor)
ISBN: 9783540113263 / Angielski / Miękka / 94 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Of all the classes in the animal kingdom, birds represent the best known. There are in total about 8600 living species, and the systematic study of this class is more or less complete. Extensive observations - to a large extent by amateur ornithologists - with respect to geographical distribution, life cycles, demands on and adaptations to the environment, breeding habits, migration, and so forth have contributed towards basic and more widely relevant knowledge, e. g., in the areas of ethology, ecology, and evo- lution and also in social biology (Hilprecht 1970; Farner and King 1971)....
Of all the classes in the animal kingdom, birds represent the best known. There are in total about 8600 living species, and the systematic study of th...
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192,30 zł |
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The Feeding System of the Pigeon (Columba livia L.)
ISBN: 9783540113324 / Angielski / Miękka / 108 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Anthropocentricity and pragmatism seem to be the main reasons why pigeons have served as the "black boxes" of so many psychologists and neurobehaviorists during the past decade. Anthropocentricity, because at first glance pigeons show several strik- ing features which bear a beautiful similarity to human systems in respects such as drinking, bipedality, territoriality, and apparently easy pursual of individual interests. Pragmatism, because of the suspected lesser complexity of the pigeon's system, which enables them to serve as good paradigms for human systems. For example, the visually...
Anthropocentricity and pragmatism seem to be the main reasons why pigeons have served as the "black boxes" of so many psychologists and neurobehaviori...
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384,63 zł |
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The Development of the Red Pulp in the Spleen
ISBN: 9783540114086 / Angielski / Miękka / 74 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In many aspects hematopoiesis in newborn rodents, especially in rats, resembles hema- topoiesis in the human fetus in the 6th-7th month of gestation. In man the transition from the stage of liver to bone marrow erythropoiesis takes place at this time (Bessis, 1973). In rodents, however, the liver is almost the only place where hematopoiesis occurs until birth. Thereafter it is replaced to a growing extent by the bone marrow, which so far consists mainly of immature mesenchymal cells (Maximow, 1910; Cuda, 1970). Thus hematopoietic precursor cells appear in the sternum only around 30 h after...
In many aspects hematopoiesis in newborn rodents, especially in rats, resembles hema- topoiesis in the human fetus in the 6th-7th month of gestation. ...
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192,30 zł |
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On the Structure of the Human Striate Area
ISBN: 9783540115120 / Angielski / Miękka / 87 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Primary cortical areas receive a defmed input which makes them especially appropria- te for investigating cortical functions. The striate area is the only isocortical field which can be delineated unequivocally in the human brain. Nevertheless, there have been only a few morphological studies of this particular area (cytoarchitectonic studies: Bailey and Von Bonin 1951, Beck 1934, Von Economo and Koskinas 1925, Filimo- noff 1932; myeloarchitectonic studies: Sanides and Vitzthum 1965, Vogt and Vogt 1919; pigmentoarchitectonic studies: Braak H 1976, 1977). For Golgi impregnations, Ramon y Cajal...
Primary cortical areas receive a defmed input which makes them especially appropria- te for investigating cortical functions. The striate area is the ...
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192,30 zł |
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The Development of the Rat Spinal Cord
ISBN: 9783540131199 / Angielski / Miękka / 168 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The study of the development of the spinal cord has a relatively long history. The spinal cord was singled out as a favorable site when cytological techniques were first applied to the study of the embryonic development of the nervous system. Bidder and Kupffer (1857), using the new procedure of hardening nerve tissue with chromic acid (Hannover 1844), made an investigation of spinal cord development in fetal sheep. They reported that the cellular central mass of the spinal cord develops before its fibrous envelope, deducing from this that the fibers of the white matter of the embryonic...
The study of the development of the spinal cord has a relatively long history. The spinal cord was singled out as a favorable site when cytological te...
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384,63 zł |
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Morphogenesis of the Brain in Staged Rhesus Monkey Embryos
ISBN: 9783540137092 / Angielski / Miękka / 72 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. During development two strongly interrelated processes can be discerned in the central nervous system (eNS), namely morphogenesis and histogenesis. Most neuroembryological studies deal with histogenetic features virtually with- out any morphological elucidation. It must be stressed, however, that histogen- etic investigations should be based upon a thorough knowledge of morphogene- sis. This holds especially for the forebrain, which during development is sub- jected to drastic transformations, particularly when only two-dimensional sec- tions are used. Therefore the present study on...
During development two strongly interrelated processes can be discerned in the central nervous system (eNS), namely morphogenesis and histogenesis. Mo...
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192,30 zł |
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Prenatal Gliogenesis in the Neopallium of the Rat
ISBN: 9783540138495 / Angielski / Miękka / 104 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. At the end of the nineteenth century, controversy arose as to precisely when the first glial cells originate during development of the central nervous system, and to date, the issue has not been satisfactorily resolved. His (1889, 1890) noted that, even in the earliest developmental stages of the germinallayer, there appeared to be two distinct cell types. The cells which he called Spongioblasten were thought to be glial precursors from which all mature glial cells derive; Keimzellen, in contrast, were regarded as forming 1 neurons. His was working on the assumption that the very first...
At the end of the nineteenth century, controversy arose as to precisely when the first glial cells originate during development of the central nervous...
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384,63 zł |
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Biomechanics of the Primate Skull Base
ISBN: 9783540152903 / Angielski / Miękka / 59 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the search for explanations for differences in the shape of skulls and their phylogenetic development, the morphology of the skull must be seen in connec- tion with the functions it has to perform. The skull encloses the brain and the sense organs and provides them with physical protection. It also houses the initial parts of the respiratory and digestive systems and together with the jaws constitutes a tool capable of cutting and grinding food. The skull must be able to withstand forces imposed upon it by chewing, by movement of the head, by the weight of the head itself, and by impact...
In the search for explanations for differences in the shape of skulls and their phylogenetic development, the morphology of the skull must be seen in ...
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384,63 zł |
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The Female Genital Tract of the Shrew Crocidura Russula
ISBN: 9783540169420 / Angielski / Miękka / 76 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Insectivores are considered to be primitive among the Eutheria and are therefore of particular interest (Romer 1966). In spite of this basal position of the group there are only few papers dealing with the structure of the female reproductive tract in insectivores. Erinaceus has been studied by Deanesly (1934), Talpa by Matthews (1935), some Centetinae from Madagascar by Feremutsch (1948) and Feremutsch and Strauss (1949), and Tenrec by Nicoll and Racey (1985). Among the Soricidae (shrews), Sorex (Brambe1l1935), Blarina (Pearson 1944), Neomys (price 1953), Suncus (Dryden 1969), and Crocidura...
Insectivores are considered to be primitive among the Eutheria and are therefore of particular interest (Romer 1966). In spite of this basal position ...
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384,63 zł |
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The Motoneuronal Organization of the Spinal Accessory Nuclear Complex
ISBN: 9783540174592 / Angielski / Miękka / 64 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Though more than 300 years have elapsed since the first description of the peculiar course of the spinal accessory (XI) nerve by Willis (1664), the crucial problems concerning what is known as accessory field of musculature and its innervation are still unsolved and a matter of controversy. Like the bulbar XI, the spinal XI nerve is commonly regarded as originally a branch of the vagus and, therefore, as a cranial nerve (Fiirbringer 1897; Gegenbaur 1898; Lubosch 1899). However, whether this nerve is of special visceral or somatic derivation is still debated. The conventional distinction...
Though more than 300 years have elapsed since the first description of the peculiar course of the spinal accessory (XI) nerve by Willis (1664), the cr...
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192,30 zł |
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The Mammalian Carotid Body
ISBN: 9783540174806 / Angielski / Miękka / 94 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. According to Valentin (1833) and Luschka (1862), the first description of the structure now known as the carotid body must be ascribed to a Swiss physiolo- gist - Albrecht von Haller - who, in 1762, called it the ganglion exiguum. This claim, however, may be erroneous, for Tauber (1743) described a struc- ture at the bifurcation on the common carotid artery and called it the ganglion minutum. Andersch (1797) reprinted the text of a study made by his father between 1751 and 1755. The original printing of this work had apparently been sold as waste paper Andersch called the organ the ganglion...
According to Valentin (1833) and Luschka (1862), the first description of the structure now known as the carotid body must be ascribed to a Swiss phys...
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384,63 zł |
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Functional Morphology of the Golgi Apparatus
ISBN: 9783540180623 / Angielski / Miękka / 96 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book gives a survey of the architecture of the Golgi apparatus, as revealed by morphological and cytochemical studies with a variety of cell types. The results presented include demonstrations of Golgi architecture in the course of cell differentiation, at varying functional cellular states, and under the influence of microtubule-disrupting agents. Emphasis is particularly placed on the organization of subsections of the Golgi apparatus and the questions of how Golgi subsections may be related to functional subcompartments of the Golgi system. By means of affinity-cytochemical...
This book gives a survey of the architecture of the Golgi apparatus, as revealed by morphological and cytochemical studies with a variety of cell type...
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cena:
192,30 zł |
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Molekulare Aspekte der Organellenontogenese
ISBN: 9783540189596 / Niemiecki / Miękka / 195 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Behandelt werden die Regulationsmechanismen auf der Ebene der Transkription, Translation und Posttranslation, die die Entwicklung der Organellen in eukaryotischen Zellen bestimmen. Der Schwerpunkt liegt dabei auf der Ausdifferenzierung von Chloroplasten und Mitochondrien in Abhangigkeit von interner Adaptation und externen Faktoren. Auf die Koordination der Regulationssignale des Kerns mit denen der Organellen wird ausfuhrlich eingegangen. Das Buch fuhrt auf der Grundlage der herkommlichen Lehrbucher fur Botanik, Genetik oder Zoologie an den augenblicklichen Stand in der molekularbiologischen...
Behandelt werden die Regulationsmechanismen auf der Ebene der Transkription, Translation und Posttranslation, die die Entwicklung der Organellen in eu...
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197,68 zł |
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Vertebral Malformations
ISBN: 9783540193593 / Angielski / Miękka / 99 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Two research centers joined to study the development of numerous malformations of the vertebral column in 30 mutants of the laboratory mouse: the Department of Anatomy of the University of Zurich, that has long been a center of research in vertebral anatomy and pathology, and the Jackson Laboratory in Bar Harbor, Maine, the largest center of research in mouse genetics. This volume describes the normal and abnormal morphogenesis of vertebrae and summarizes the data presently available in order to give better insight into the developmental mechanics of the vertebral column.
Two research centers joined to study the development of numerous malformations of the vertebral column in 30 mutants of the laboratory mouse: the Depa...
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384,63 zł |
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Granulated Metrial Gland Cells
ISBN: 9783540503903 / Angielski / Miękka / 112 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. 1. 1 Historical Aspects and Terminology Granulated metrial gland (GMG) cells are readily identified by their cytoplasmic granules and were observed a number of years before the term "metrial gland" was introduced. A series of papers by Duval in 1891 provided a comprehensive description and a critical review of earlier studies of the placenta of rodents, but it was not until 1902 that the first convincing illustrations of GMG cells appeared in the literature (Jenkinson 1902). Jenkinson described "maternal glycogen cells" in the pregnant mouse uterus and noted that they contained cytoplasmic...
1. 1 Historical Aspects and Terminology Granulated metrial gland (GMG) cells are readily identified by their cytoplasmic granules and were observed a ...
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cena:
384,63 zł |
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