Kategoria BISAC: Health & Fitness >> Diseases & Conditions - Genetic

There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus,...

This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction,...

This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology, and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book,...

This volume provides a comprehensive, up-to-date overview on pediatric and adolescent gynecological endocrinology. It covers a very wide range of topics with a particular focus on disorders of sex differentiation, pubertal maturation, growth disorders, primary and secondary amenorrhea, menstrual disorders in adolescents and young adults, sexuality, contraception, and pregnancy. The authors are international well-known experts who document the latest clinical experience in this continuously evolving field and provide practical guidance on the evaluation and treatment of female pubertal...

Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden.

The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of,...

This volume presents the scientific advances and current status of our understanding of precision medicine for common diseases in gynecology and obstetrics. Standard treatments based on clinical guidelines in the field have been established for decades, and those are essential to daily clinical practice. Meanwhile comprehensive genomic and genetic analyses have led to personalized medicine by precise clinical and genomic approaches. This book is organized into two major parts, gynecology and obstetrics, and the chapters in each part give a clear exposition of the current knowledge and the...

This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into...

​​To many patients and indeed health care professionals, IVF is the ultimate treatment for infertility. However in many cases IVF is not feasible and may not be indicated. IVF remains a largely inefficient procedure that often does not succeed in a achieving a pregnancy.

There remains a strong place for other fertility interventions, many of them surgical in nature. Surgical interventions can be used as a stand-alone fertility treatment or as an adjuvant treatment used in conjunction with other assisted conception treatments. Despite the continuing use of such techniques...

Worldwide, the World Health Organization estimates that 346 million people have diabetes, a figure that is expected to double by 2030 without intervention. In this essential resource for any diabetes sufferer, Professor Merlin Thomas from the world-renowned Baker IDI Heart & Diabetes Institute offers clear, effective guidance on how to manage all aspects of the disease. The book examines what diabetes is and how it comes about. It describes the many practical changes you can make to your diet, while also looking at physical activity and the different ways exercise can be used to maintain...

This book offers a cutting-edge guide to hysteroscopy and provides readers with the latest and most essential information on procedure techniques, clinical advances and international developments in practice and treatment of endometrial pathology. Providing comprehensive coverage, it explains in detail every aspect of hysteroscopy, from diagnostics to hysteroscopic surgery. As such, it addresses the bases of hysteroscopy; pre-, intra- and post-hysteroscopy medications; intracavitary pathologies; fertility issues; and surgical implications and complications. At the same time, it also...