Discovered in 1961, amiodarone is a cationic amphiphilic molecule which belongs to class III antiarrhythmic drugs and therefore, it is used in the treatment of a wide range of cardiac arrhythmias. Advances in Medicine and Biology. Volume 136 begins by discussing state of the art formulations of amiodarone and outlooks for future dosage forms. Though amiodarone hydrochloride has often been prescribed for patients with refractory or life-threatening arrhythmias, its clinical use is frequently limited because of a number of side effects such as corneal microdeposits, photosensitivity, pulmonary...

Advances in Medicine and Biology. Volume 140 opens by discussing vascular endothelial growth factor, an attractive target for antiangiogenic therapy for glioblastoma. Although bevacizumab, a humanized anti-vascular endothelial growth factor antibody, improves the progression-free survival of patients with glioblastoma, prolonged overall survival has been attained only in few patients with a proneural type of glioblastoma. As such, bevacizumab is increasingly used to treat newly diagnosed and recurrent glioblastoma.Bevacizumab selectively inhibits glioblastoma growth by targeting...

In Advances in Medicine and Biology. Volume 138, the authors reflect on the development of ethically reliable procedures that keep in line with cultural traits while guaranteeing proper implementation of the fundamental principles of bioethics, within the framework of ethically binding biomedical research. As such, this write-up gives an overview on the ethical implications and regulatory issues governing African traditional medicine research practices in Cameroon.This collection goes on to present the relationship between riboflavins chemical properties and its exploitable applications in...

The authors of the opening chapter of Advances in Medicine and Biology. Volume 142 provide recommendations and tips to assist medical oncologists, hematologists and clinicians in investigating and managing early catheter malfunction. The aim of the following chapter is to ease prompt recognition and management of central venous catheter-related infectious outbreaks, as they may severely jeopardize the outcome of infected patients Next, the placement and maintenance of central venous access devices in the neonatal patient population, with particular regard to umbilical catheters and...

The opening chapter of Advances in Medicine and Biology. Volume 144 summarizes the generation of amniotic fluid, role and its clinical significance of protecting the fetus from external trauma. Next, the role of in silico and in vitro methods are used for the prediction of cytotoxicity which is measured in terms of Selectivity Index or Therapeutic Index, which is defined as the ratio of CC50 and EC50. Additionally the authors discuss the principles of aptamer selection and in vitro applications for bench scientists in molecular imaging, including aptahistochemistry, tissue imaging,...