Objective: The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. Methods: The 32factorial design was used to preparation of compression-coated with a mixture of time dependent hydrophilic swellable polymer hydropropylcellulose (HPC), time released polymer Ethyl cellulose (EC) and pH responsive soluble polymer Instacoat EN Super II. The developed formulations were characterized for angle of repose, density, carr's index of powder mixture and thickness, diameter, hardness, friability, weight variation, uniformity content, in vitro...

The objective of the present investigation was to development of Zolmitriptan (ZMT) niosomal in-situ nasal gel formulation for treatment of migraine. The intranasal route could delivered drug to the central nervous system (CNS) through the olfactory lobes, which helps to circumvent the blood brain barrier (BBB), which bypasses first pass metabolism and consequently enhances the bioavailability of the drug. ZMT niosomes were prepared using lipid film hydration technique. Optimized niosomal formulation was used for preparation of in situ gel formulation. The developed formulations were...