Für die gleichzeitige Schätzung von Norfloxacin und Tinidazol in pharmazeutischen Darreichungsformen wurden zwei einfache, genaue und reproduzierbare spektrophotometrische Methoden entwickelt. Die erste Methode umfasst die Bestimmung mit der AUC-Methode (Area Under Curve Method); die gewählten Probenahmewellenlängen sind 272-282 nm und 313-323 nm über die Konzentrationsbereiche von 2-12mig/mL bzw. 3-18 mig/mL für Norfloxacin bzw. Tinidazol. Die zweite Methode umfasst die Bestimmung mit der Q-Analyse-Methode (Absorptionsverhältnis-Methode); die gewählten Probenahmewellenlängen sind...

The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at...

Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size,...

The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner's ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with...