Diclofenac Potassium Tablet for Colon Targeting: Formulation

ISBN-13: 9786206181217 / Angielski / Miękka / 52 str.

Anilkumar Shinde; Ravindra Jarag; Harinath More

Opis

The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7-8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study.

O autorze

Dr. Anilkumar J. Shinde, M.Pharm Ph.D he started career in Pune university, Pune as Lecturer in Pharmaceutics & younged in teaching since 1994. Presently he is working as Associate Professor in Pharmaceutics Department at Bharati Vidyapeeth College of Pharmacy, Kolhapur.