The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at...

Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size,...

The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner's ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with...

L'objectif de ce travail était de préparer des systèmes d'administration spécifiques au côlon pour l'acide 5-aminosalicylique (5-ASA) en utilisant la gomme de fenugrec et le chitosane comme vecteur ciblant le côlon. Méthodes : Des comprimés de base contenant du 5-ASA ont été préparés par granulation humide en utilisant la pyrolidone de polyvinyle (PVP) comme liant et le glycolate d'amidon de sodium comme super désintégrant. Les granulés préparés ont été évalués pour l'angle de repos, l'indice de compressibilité et le rapport de Hausner. Les comprimés préparés ont fait...

Das Ziel der vorliegenden Arbeit war die Herstellung von Dickdarm-spezifischen Verabreichungssystemen für 5-Aminosalicylsäure (5-ASA) unter Verwendung von Bockshornklee und Chitosan als Träger für den Dickdarm. Methoden: 5-ASA-haltige Kerntabletten wurden durch Nassgranulation unter Verwendung von Polyvinylpyrolidon (PVP) als Bindemittel und Natriumstärkeglykolat als Superzerfallsmittel hergestellt. Das hergestellte Granulat wurde auf den Schüttwinkel, den Kompressibilitätsindex und das Hausner-Verhältnis untersucht. Die vorbereiteten Tabletten wurden auf ihre Härte, Brüchigkeit,...