Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Norfloxacin and Tinidazole in pharmaceutical dosage forms. The first method involves determination using the AUC Method (Area Under Curve Method); the sampling wavelengths selected are 272-282 nm and 313-323 nm over the concentration ranges of 2-12mig/mL and 3-18 mig/mL for Norfloxacin and Tinidazole respectively. The second method involves determination using the Q-Analysis Method (Absorbance Ratio Method); the sampling wavelengths selected are 277 nm and 318 nm over the...

Ziel der vorliegenden Studie war es, die Diltiazemhydrochlorid-Konzentration in einem gewünschten Bereich zu halten, die Dosierungshäufigkeit zu verringern und die Bioverfügbarkeit zu erhöhen. Die Tabletten wurden mit Hilfe eines 32-faktoriellen Designs formuliert. Die Wirkung der unabhängigen Variablen X1 (Konzentration von Hydroxypropylmethylcellulose K100) und X2 (Konzentration von Natriumcarboxymethylcellulose) auf den Quellungsindex und die Wirkstofffreisetzung wurde untersucht. Die Tabletten wurden durch direkte Kompression mit einem 13-mm-Stempel auf einer...

Biodegradable microspheres are one of the most useful devices to deliver materials in an effective, prolonged and safe manner. Mucoadhesion is a novel area of interest in the design of drug delivery systems to maintain the dosage form at the site of action or absorption and to facilitate intimate contact of the dosage form with underlying absorption surface to improve and enhance bioavailability. Repaglinide is a meglitinide analogue used as oral hypoglycaemic drug and having very low t1/2 (~ 1hr.), 56% bioavailability. It is totally absorbed from GIT, so it is the need to increase its...

The present study was to maintain the levels of diltiazem hydrochloride within a desired range, reduction in its dosing frequency and increase bioavailability. The tablets were formulated by using of 32 factorial design, the effect of independent variables X1 (concentration of hydroxy propyl methylcellulose K100) and X2 (concentration of sodium carboxymethylcellulose) on swelling index and drug release was studied. Tablets were prepared by direct compression method using 13 mm punch on rotary tablet machine. Physical properties of compressed tablets such as hardness, friability, content...

The objective of present study was to formulate an oral mcoadhesive tablet of diltiazem hydrochloride.Investigate the effect of amount of HPMC K4M and sodium alginate on the sustained release and gastric residence time of dosage form. The mucoadhesive tablet prepared by direct compression method was used varying concentrations of HPMC K4M and Sodium alginate and (1:1, 1:1.5, 1:2) Drug and Polymer ratio.The formulations were evaluated and results revealed that FTIR studies showed no evidence of interactions between drug and excipients used. The mucoadhesive strength, residence time and drug...