This study aimed to assess seminal sirt-1 in infertile men associated with varicocele (Vx). Patients and Methods: Overall, 54 men presented to the University hospitals after ethical approval and informed consent were investigated. They were allocated into; fertile men (n=14), infertile OAT men without Vx (n=23) and infertile OAT men with Vx (n=17). Inclusion criteria for the patients: Stable relationship, confirmed abnormal semen parameters and normal female partner. Exclusion criteria were; Leucocytospermia, hormonal therapy, immunological disorders, dyslipidemia, hypogonadism, hypertension,...