The aim of this systematic review was to investigate and compare the diagnostic accuracy including sensitivity, specificity, adjusted accuracy, adjusted positive predictive value (PPV), and adjusted negative predictive value (NPV) of cold pulp testing (CPT), electric pulp testing (EPT), laser Doppler flowmetry (LDF), and pulse oximetry (PO).Methods: Three electronic databases were searched from 1st January 2000 to 1st November 2020. True- positive, false-positive, true-negative, and false- negative values were extracted from data in each study. Sensitivity, specificity, adjusted accuracy,...

L'objectif de cette revue systématique était d'étudier et de comparer la précision du diagnostic, y compris la sensibilité, la spécificité, la précision ajustée, la valeur prédictive positive ajustée (VPP) et la valeur prédictive négative ajustée (VPN) du test de la pulpe froide (CPT), du test de la pulpe électrique ( EPT), débitmétrie laser Doppler (LDF) et oxymétrie de pouls (PO). ont été extraites des données de chaque étude. La sensibilité, la spécificité, la précision ajustée, la VPP ajustée et la VPN ajustée ont été calculées à partir de ces valeurs, si...

Das Ziel dieser systematischen Überprüfung war es, die diagnostische Genauigkeit einschließlich Sensitivität, Spezifität, angepasste Genauigkeit, angepasster positiver prädiktiver Wert (PPV) und angepasster negativer prädiktiver Wert (NPV) von Cold Pulp Testing (CPT), Electric Pulp Testing ( EPT), Laser-Doppler-Flowmetrie (LDF) und Pulsoximetrie (PO). Methoden: Vom 1. Januar 2000 bis 1. November 2020 wurden drei elektronische Datenbanken durchsucht. Richtig positive, falsch positive, richtig negative und falsch negative Werte wurden aus den Daten in jeder Studie extrahiert....

Bilayer tablet has been made and evaluated. For various precompression and post compression parameter. Precompression parameter shows that the granules and blends of repaglinide and saxagliptin have good Carr's index and hausner's ratio indicate that both granules and blends were free flowing. The angle of repose shows that granules and blends have excellent flow and post compression parameter show that bilayer tablet have thickness hardness and weight and friability within the I. P. limit and bilayer tablet have swelling index 82% in 6 hrs and have drug release first layer of saxagliptin...

The preformulation studies involves description, solubility, melting point, of the drug were found to be comparable with the standard. Based on the all above preformulation studies the drug was suitable for making the transdermal formulation. Based on all these factors the transdermal drug delivery system F5 was having greater % drug release. The formulation F5 shows better extended release up to 24hrs when compared to other formulations. So it was concluded that the formulation F5 prepared by using Eudragit RS100 and HPMC is the better formulation for control release of drug up to 24hrs of...

In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide.Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate..Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is...

The book entitled "Computational studies among the Metallopharmaceuticals compound" include field of science that combines mathematics with chemistry is called computational chemistry. It is responsible for obtaining a relationship called quantitative structure-property relationship (QSPR) or structural work relationship (QSAR). QSAR, the most widely used terminology based on a network communication (SAR) method. QSAR is the study of how the physicochemical properties of a series of compounds affect their biological activity. Physiochemical features or theoretical definitions of chemical or...