FORMULATION EVALUATION OF BILAYER TABLET OF SAXAGLIPTIN & REPAGLINIDE

ISBN-13: 9786206142898 / Angielski / Miękka / 104 str.

Anjali Soni; Dharmendra Solanki; PRIYANKA YADAV

Opis

In the present research work, an attempt has been made to optimize and formulate bilayer tablet of saxagliptin and repaglinide to achieve immediate release of saxagliptin and sustained release of repaglinide.Saxagliptin is DPP-4 inhibitor and belonging to BCS class 1 (high solubility, high permeability). It has long half life, so an attempt was made to achieve its fast action by making immediate release tablet by using superdisintegrant sodium starch glycolate..Repaglinide is an oral blood glucose-lowering drug of the maglitinide class used in the management of type 2 diabetes mellitus. It is absorbed by oral route and has short half life, so an attempt has been done to make sustained release tablet of repaglinide And it was concluded that the optimized formula RG4 (75 mg) drug (98.6 %) in 12 hrs. So by taking both optimized formulation in fixed dose combination in different layer. A bilayer tablet was prepared with 50 mg saxagliptin and 500 mg of repaglinide.

O autorze

Anjali Soni currently working as assistant professor at LNCP Indore. She has three years of experience in academics, she did M.pharma from AIPER Indore and B.pharma from BRNCOP Mandsour. She had published two research paper and many are communicated with journals. She is also a member of APTI.