Supersaturable SMEDDS appeared to be an interesting approach to alleviate problems associated with oral delivery of Nebivolol. This can be achieved by using NEB-SMEDDS having the formula as Castor oil (30 %,v/v), Tween-80 (35 %,v/v), PEG-400 (35 %,v/v) and HPMC(5%)was successfully optimized to achieve higher release as well as bioavailability of NEB in F8 formulation of SMEDDS in comparison to plain drug suspension. Stability of the formulation was confirmed by thermodynamic stability study and long term stability study. The release and bioavailability from F8 SMEDDS was increased due to...

The combination of Telmisartan and Cilnidipine is play a vital role in the treatment of the patient suffering from Hypertention. Hence this present work provides a very simple and accurate method for simultaneous estimation of Telmisartan, Cilnidipine. In simultaneous equation method, wavelength selected for analysis were 299nm for Telmisartan and 242nm for Cilnidipine. The method linearity is observed in the concentration range and 5-45mig/ml for Telmisartan and for Cilnidipine is 4-24mig/ml, with good correlation coefficient 0.998 and 0.991 respectively.

The carpaine was isolated from Carica papaya L. leaf, was identified by means of Fourier transform infrared spectroscopy, mass spectrometry, nuclear magnetic resonance, HPLC and was determined by LCMS, The powder of dried leaves was macerated and extracted with Methanol/water/HCl (89:10:1 V/V/V) to produce crude alkaloid. The extract was fractionated on a silica gel column chromatography using methanol/chloroform (5:95 v/v) as the eluate. The major fraction was isolated according to Rf values of thin-layer chromatography (TLC) (silica gel, methanol/chloroform [15:85 v/v]) exposed by...

La carpaïne a été isolée de la feuille de Carica papaya L., a été identifiée par spectroscopie infrarouge à transformée de Fourier, spectrométrie de masse, résonance magnétique nucléaire, HPLC et a été déterminée par LCMS. La poudre de feuilles séchées a été macérée et extraite avec du méthanol/eau/HCl (89:10:1 V/V/V) pour produire l'alcaloïde brut. L'extrait a été fractionné sur une colonne de chromatographie sur gel de silice en utilisant le méthanol/chloroforme (5:95 v/v) comme éluat. La fraction principale a été isolée selon les valeurs Rf de la...

Das Carpaine wurde aus den Blättern von Carica papaya L. isoliert und mittels Fourier-Transformations-Infrarot-Spektroskopie, Massenspektrometrie, kernmagnetischer Resonanz und HPLC identifiziert und mittels LCMS bestimmt. Das Pulver der getrockneten Blätter wurde mazeriert und mit Methanol/Wasser/HCl (89:10:1 V/V/V) extrahiert, um ein rohes Alkaloid zu erhalten. Der Extrakt wurde auf einer Kieselgelsäule unter Verwendung von Methanol/Chloroform (5:95 v/v) als Eluat fraktioniert. Die Hauptfraktion wurde anhand der Rf-Werte der Dünnschichtchromatographie (TLC) (Kieselgel,...