Objective: The present study was undertaken to evaluate the anti-stress effect of RNH-12 on experimental induced stress in rat.Methodology: The anti-stress effect was evaluated on cold restraint induced stress, and swimming endurance stress induced. RNH-12 was administered orally at two different doses of 40 and 60 mg/kg. Withania somnifera, a known anti-stress formulation (500 mg/kg p.o) was used as the standard drug.Results: Both the doses of RNH-12 showed good anti-stress effect in all the tested animal models. The RNH-12 reduced the development of cold restraint induced gastric ulcers and...