Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to...

Nanohydrogels are the hydrogels that are prepared in water by self-aggregation of polymers of natural origin like dextran. These types of hydrogels are formed from natural polysaccharides like dextran, pullulan, or cholesterol-containing polysaccharides.Polymeric micelles have several advantages over other nanosized drug delivery systems, such as a smaller size as compared to, for instance, liposomes, which is important for, e.g., percutaneous lymphatic delivery or extravasation from blood vessels into the tumor tissue. Polymeric micelles are based on block-copolymers with hydrophilic and...