Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2 3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The...

Die sich entwickelnde Technologie und die Integration digitaler Lösungen in die Praxis haben die Diagnose und Behandlungsplanung von einem traditionellen zweidimensionalen (2D) Ansatz in eine fortschrittliche dreidimensionale (3D) Technik verwandelt. Kieferorthopäden werden durch die zunehmende Anzahl und Komplexität dieser Systeme und Software herausgefordert. Die kontinuierliche Weiterentwicklung von Maschinen, Techniken und Software hat die diagnostischen Möglichkeiten verbessert, und es wird erwartet, dass die kraniofaziale Bildgebung in naher Zukunft vollständig digital sein wird.

Evolving technology and integration of digital solutions in practice have transformed diagnosis and treatment planning from a traditional two-dimensional (2D) approach into an advanced three-dimensional (3D) technique.Orthodontists are challenged by the increasing number and complexity of these systems and software. The continuous advancements in machines, techniques, and softwares have improved the diagnostic capabilities.Craniofacial imaging is expected to become totally digital in the near future.