Pyrazoline Derivatives as Antitubercular Agents

ISBN-13: 9783848406340 / Angielski / Miękka / 92 str.

Vaibhav Jain; Priyal Jain; Surendra Jain

Opis

Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2 3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.

O autorze

Mr. Vaibhav Jain, Asst. Prof. SIRT-Pharmacy, Bhopal; has degree of M.Pharmacy with specialization in Pharmaceutical Chemistry. He is the author of numerous scientific publications along with various presentations in National & International Conferences. He was associated with Central Drug Research Institute,Lucknow during his research work.