The study of bone fracture and healing is a very challenging job in orthopedic surgery. In the present perspective of this endeavor is to document of ever increasing growth factors and their respective roles to get a successful repaired bone. Therefore the present study envisage the healing of bone fractures and the role of growth factors like TGF-ß1, IGF-1, FGF, PDGF, VEGF and bone morphogenetic proteins-2 and 7 in healing mechanism. In this book a comparative efficacy of TGF- 1, IGF-1 and the combined application of TGF- 1 and IGF-1 was evaluated in augmentation of segmental bone healing....