Growth Factors vis-a-vis Healing of Bones

ISBN-13: 9783848431526 / Angielski / Miękka / 168 str.

Shyamal Kanti Guha; Sagar Tirtha Sarkar

Opis

The study of bone fracture and healing is a very challenging job in orthopedic surgery. In the present perspective of this endeavor is to document of ever increasing growth factors and their respective roles to get a successful repaired bone. Therefore the present study envisage the healing of bone fractures and the role of growth factors like TGF-ß1, IGF-1, FGF, PDGF, VEGF and bone morphogenetic proteins-2 and 7 in healing mechanism. In this book a comparative efficacy of TGF- 1, IGF-1 and the combined application of TGF- 1 and IGF-1 was evaluated in augmentation of segmental bone healing. We observed that the combined application of TGF- 1 and IGF-1 stimulated the production of osteoblasts that transformed into osteocytes produced synergistic osteoinductive effect in augmentation of fracture healing and remodeling process in combo group as compared to apply singly. I want to express my sincere wishes to Dr. S. Sarkar and Prof. Subhashis Biswas for their inspiring attitude that increased the strength for such work. Finally I want to express my sincere gratitude to my wife Sipra and son Himanish for their constant support.

O autorze

Dr. Shyamal Kanti Guha, born at Kolkata, West Bengal, India in the year of 1964; studied at Bidhan Chandra Krishi Viswa Vidyalaya (Graduation); TANUVAS (Masters degree in Veterinary Surgery & Radiology); West Bengal University of Animal and Fishery Sciences, Kolkata (Ph.D.).Associate Professor at W.B.U.A.F.S.