In the present time in market new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. There is various application of the bi-layer tablet it consist of monolithic partially coated or multilayered matrixes .bi-layer tablet is a very different aspect for anti inflammatory ,anti diabetics , analgesic and antidepressant...

The objective of the research work was to design novel proniosomes containing highly potent drug tretinoin. In this research work, proniosomes have been prepared by all the three known methods which are COACERVATION PHASE SEPARATION METHOD, SLURRY METHOD and third SLOW SPRAY COATING METHOD. In first method that is coacervation phase separation method the amount of cholesterol and phospholipids were kept constant but the different surfactants are used in varying ratios which has effect on drug entrapment, vesicle size and entrapment efficiency of prepared proniosomes. The proniosome...

In the present study carboxylic group of Etodolac, responsible for gastric side effects, was masked temporarily not only to overcome the side effects but also to achieve colon specific delivery. Amide prodrug (Etodolac-glycine conjugate) was synthesized by coupling Etodolac with glycine The synthesized prodrug was characterized by melting point, thin layer chromatography, RM values, scanning electro microscopy, x-ray diffraction crystallography and High performance liquid chromatography. Aqueous solubilities and lipophilicity (log P) values were determined at different pH media namely HCl...

In the present work a oral polymeric microsponge formulation of etodolac has been developed. The study includes formulation and evaluation of etodolac microsponges. The idea behind developing a oral polymeric microsponge delivery system was to deliver Etodolac in a sustained release pattern for an extended period of time to reduce frequency of taking and improve patient compliance. To begin with, the variables involved (viz. selection of internal and external phase, selection of type and concentration of emulsifier, selection of speed and time of stirring required for preparation) in the...

The objective of the research work was to design novel liposomes containing both hydrophilic and hydrophobic drug by using modified ethanol ejection method was used to formulate liposomes and optimize based on 32 full factorial design. The effect of independent variables was determined on dependent variables. The liposome formulation F9 showed higher drug entrapment and controlled drug release. Small multilamellar vesicles, with sizes ranging from about 117 to 200 nm, were successfully obtained. Results indicated a significant influence of phospholipid amounts on liposome size and...

The aims of the research work were (1) preparation and evaluation of nanofibers using mupirocin for treating primary and secondary burns by solvent casting method. (2) Preparation and evaluation of nanofibers using mupirocin for treating primary and secondary burns by electrospinning method. (3) Comparison of both the methods used for preparation of nanofibers for better and efficient treatment of burns. In this study we had used mupirocin for the treatment of burn. This study estimated the topical potential of nanofibers incorporated with mupirocin for treating burns, to compare traditional...

Solid lipid nanoparticles(SLNs) have been proposed as suitable colloidal carriers of drug with limited solubility. Ibuprofen SLNs prepared from mixture of Bees wax, Carnauba wax, and Ozokerite wax using Tween 80 as Surfactant. The characteristics of the SLNs with various lipids and surfactant composition were investigated. The mean particle size of drug loaded SLNs decreased upon mixing with Tween 80 as well as upon increasing total surfactant concentration. The zeta potential of these SLNs varied in the range of -1.58 to -24.4(mV), suggesting the presence of similar interface properties....

In the present work we aimed our investigation to prepare and evaluate the Lipid microspheres of an Anti-inflammatory drug i.e. Aceclofenac in order to control the drug release, to enhance the bioavailability and to minimize gastrointestinal side effects. For the preparation of Lipid microspheres, melt dispersion technique was used. Paraffin wax and stearic acid were used as excipients. The prepared Lipid microspheres formulations were evaluated for different parameters like particle size analysis, drug content, entrapment efficiency, and SEM, XRD, DSC, and invitro release studies.

"Ethosomes are ethanol liposomes" was developed by Touitou et al., 1997 are non invasive soft vesicles delivery carriers that enable drugs to reach the deeper layer or the systemic circulation. The aim of present study was to assess the topical potential of ethosomes loaded with melatonin for the prevention of melatonin. It was done by encapsulating the drug in various ethosomal formulations composed of various ratios of ethanol, soya lecithin and cholesterol prepared by cold method. The prepared ethosomal formulations were characterized for particle shape, vesicle size, zeta potential, drug...

Leflunomide is a drug with limited water solubility. It exhibits four polymorphic forms I,II,III,IV. In the present study, form II polymorph was formulated using form I. Form II polymorph readily dissolves in water than does form I. The crystals of form I and II polymorph were characterized by IR, DSC, XRPD. Comparison of solubility of form I and form II was done by UV Spectrophotometer. There was a significant increase in solubility of form II. Aqueous film-coated tablets of form I and form II were prepared using the same processing parameters and compared for the rate of dissolution. Form...