Maintaining good metabolic profile plays a significant role in improving the quality of life at aging. Widely recommended physical and psychological strategies include exercise, calorie restriction (such as healthy diet), anti-aging neuroprotective and anti-inflammation therapy. Most occurring risks at middle age range (45-65 years old) are obesity, insulin resistance, inflammation, alteration in the hypothalamus-hypophysis suprarenal axis activity, stress and hypertension that could increase the prevalence of metabolic syndrome. Metabolic syndrome increases with age, particularly for women. ...

Neuroimaging techniques that can help elucidate and characterise the nature and mechanism of tissue injury and disease progression in neurodegenerative disease are of particular importance given its their roles in seeking successful preventive and therapeutic treatments. Studying large-scale samples with various disease mechanisms using multi-parametric imaging, as well as revealing the correlations between the neuroimaging metrics and clinical data including neurocognitive function and neuropsychological inventories to elucidate multiple factors affecting the neurodegeneration processes in...

The well-known Alzheimer's Disease Neuroimaging Initiative (ADNI) Center provides the most advanced, comprehensive, multiparametric and up-to-date biomarkers for mild cognitive impairment (MCI) and early Alzheimer's disease (AD) projects, including neuroimaging, clinical assessments, biospecimens and genetic data. Recent developments in imaging techniques, including new molecular tracers for imaging disease burden and systematic multi-modal integration, have emerged to overcome the limitations of each single modality and individual-dependent variability. The MRI-based high-resolution...

Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio...

The aim of this new book is to provide readers some new insights into applying various imaging techniques to diagnose and distinguish subtypes and rare/comorbid cases of several brain disorders more accurately. Specific and comprehensive imaging features utilized that could pinpoint the exact abnormalities of these atypical and/or rare diseases are the highlights of this book, which will provide guidance for better disease mechanism interpretation.