This book constitutes the proceedings of the 11th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022, held as virtual event, in July 19–22, 2022. The conference was held virtually due to the COVID-19 crisis.The 30 full papers and 8 short papers presented were carefully reviewed and selected from 48 submissions. They deal with research on novel life-like technologies inspired by the scientific investigation of biological systems; biomimetics; and research that seeks to interface biological and artificial systems to create biohybrid systems.