Chemical exchange saturation transfer (CEST) imaging is a powerful magnetic resonance imaging (MRI) technique with unique contrast features. This technology enables the amplified detection of nM to mM concentrations of small molecules and macromolecules (including those involved in biologic pathways) through selective radio frequency labeling of rapidly exchanging protons present on the molecules of interest. Because this labeling is frequency dependent, CEST agents have advantages over the more established water relaxation based contrast agents, making them more similar to optical imaging...