Over expression of 11 -HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11 -HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11 -HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11 -HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and...