In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity » książka
In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity
ISBN-13: 9783659790010 / Angielski / Miękka / 2015 / 56 str.
Over expression of 11 -HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11 -HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11 -HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11 -HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 -HSD 1 analog of corosolic acid without nephrotoxicity."
Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinskis rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.
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