Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 & 2:1) by co-processing and physical mixing. The result showed that the formulation containing co-processed superdisintegrant in the ratio of 1:2 (CP2) showed faster disintegration, wetting, dispersion and maximum...
Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its ...