Novel Co-Processed Superdisintegrants for Sublingual Tablets » książka
Novel Co-Processed Superdisintegrants for Sublingual Tablets
ISBN-13: 9783659696855 / Angielski / Miękka / 2015 / 112 str.
Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 & 2:1) by co-processing and physical mixing. The result showed that the formulation containing co-processed superdisintegrant in the ratio of 1:2 (CP2) showed faster disintegration, wetting, dispersion and maximum drug release. The disintegration time of optimized formulation (CP2) was upto 7 sec. The % in vitro drug release of Enalapril Maleate was 100.52 % in 3 min. Ex vivo permeation of CP2 was found to be 92.260.96% in 6 min. Thus, from the present work it reveals that the co-processed superdisintegrants formulation are superior to physical mixture formulation. Sublingual tablets of Enalapril Maleate gives faster drug release because of presence of superdisintegrants and may improve bioavailability of Enalapril Maleate.
Enalapril Maleate is anti-hypertensive drug and its oral bioavailability is 40%. Sublingual tablets of Enalapril Maleate were prepared to improve its bioavailability, to avoid pre-systemic metabolism and hepatic first pass elimination. Tablets were prepared by wet granulation technique using two different superdisintegrants KYRON-T-314 and INDION-414 in the different ratio (1:1, 1:2 & 2:1) by co-processing and physical mixing. The result showed that the formulation containing co-processed superdisintegrant in the ratio of 1:2 (CP2) showed faster disintegration, wetting, dispersion and maximum drug release. The disintegration time of optimized formulation (CP2) was upto 7 sec. The % in vitro drug release of Enalapril Maleate was 100.52 % in 3 min. Ex vivo permeation of CP2 was found to be 92.26±0.96% in 6 min. Thus, from the present work it reveals that the co-processed superdisintegrants formulation are superior to physical mixture formulation. Sublingual tablets of Enalapril Maleate gives faster drug release because of presence of superdisintegrants and may improve bioavailability of Enalapril Maleate.
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