The present study investigates the possible mechanism of erythropoietin (EPO) mediated benefits in mouse model of streptozotocin (icv) induced dementia. Morris water maze test was employed to assess memory of the mice. Biochemical-estimations like brain acetyl cholinesterase (AChE) activity, brain nitrite/nitrate and total oxidative stress levels were also performed. Streptozotocin (STZ) produced a significant decrease in water maze performance of mice reflecting impairment of memory. STZ also produced a rise in brain AChE activity, nitrate/nitrite & oxidative stress levels. Treatment of EPO...

The present study was designed to investigate the antiglycation potential of hydro-alcoholic and alkaloidal fractions of selected plants. Seeds of Trigonella foenum-graecum, bulbs of Allium sativum, fruits of Momordica charantia. and leaves of Gymnema sylvestre were selected. The protein glycation inhibitory activity of these plants was evaluated using glucose-bovine serum albumin assay. Among the hydroalcoholic extracts, Trigonella-foenum graecum showed highest antiglycation activity (IC50 = 53.53 1.24 ug/ml) followed by Allium sativum (IC50 = 68.36 1.56 ug/ml), Momordica charantia (IC50 =...

Stroke is the third most common cause of death and has profound negative social and economic effects. The failure, of various clinical trials of exogenously administered drugs as potential stroke therapy has enhanced the ongoing search to identify endogenous mechanisms activated after cerebral ischemia that might be harnessed as neuroprotectants in stroke. Postconditioning (PoCo), is an adaptive technique, whereby brief repetitive cycles of ischemia with intermittent reperfusion immediately following prolonged ischemia elicits tissue protection. Protective role of PoCo has been reported in...