Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of the gastrointestinal (GI) tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems, raft systems, expanding systems, swelling systems, bioadhesive systems and low-density systems. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region.This book consists of detail aspect of gastroretentive drug delivery systems. Authors...

This book describes the design and evaluation of multiple unit pellet system (MUPS) for dual drug delivery i.e. sustained release ofloxacin and colon targeted ornidazole to treat dysentery as an alternative to conventional formulations. It involves a detailed procedural aspects for formulation and coating of pellets with Eudragit RS100 and Eudragit S100. It also describes an in vitro evaluation of pellets for various parameters along with in vivo colon targeting. The book describes the DOE approach for the Ofloxacin sustained release pellets optimization using full factorial design. It...