Dual Drug Delivery System Containing Ornidazole and Ofloxacin

ISBN-13: 9783659396052 / Angielski / Miękka / 2015 / 108 str.

Patel Dasharath M.;Soneji Jignesh a.;Patel Chhagan N.

Opis

This book describes the design and evaluation of multiple unit pellet system (MUPS) for dual drug delivery i.e. sustained release ofloxacin and colon targeted ornidazole to treat dysentery as an alternative to conventional formulations. It involves a detailed procedural aspects for formulation and coating of pellets with Eudragit RS100 and Eudragit S100. It also describes an in vitro evaluation of pellets for various parameters along with in vivo colon targeting. The book describes the DOE approach for the Ofloxacin sustained release pellets optimization using full factorial design. It describes the modeling of dissolution kinetics. In vivo X-ray images showed similarity with in vitro release profile that pellets disappear only after reaching to colon. Multiple unit pellet system provided extended release of ofloxacin and delivery of ornidazole to colon providing an alternative for conventional formulations in treatment of amoebic dysentery with reduced side effects. Drug-excipient compatibility study revealed no interaction between drug and excipients. Optimized formulation showed good stability at accelerated environmental conditions.

O autorze

Dr. D. M. Patel, Professor, Shri Sarvajanik Pharmacy College, Mehsana has a rich experience of 15 yr. He has 60 research publications, 4 books and 1 Patent to his credit. He has delivered 25 expert lectures, guided 30 PG and 07 Ph.D students. He has received a research grant of Rs 32 lakhs. He is a Lifetime member of IPA, APTI, APP and GPTA.