Chemokines constitute a large family of structurally similar cytokines that contain a signature of conserved cysteine residues joined by disulfide bridges. Binding of chemokines to specific G protein-coupled receptors followed by downstream signaling defines their biological function. Initially, chemoattraction was the key function linked to chemokines/chemokine receptors; however, in recent years, it has become clear that chemokine ligand-receptor interactions can also modulate cellular activation, survival, and proliferation, among other functions in homeostatic and diseased states....
Chemokines constitute a large family of structurally similar cytokines that contain a signature of conserved cysteine residues joined by disulfide ...
This Methods in Molecular Biology book offers experimental models and state-of-the-art methods used to delineate chemokine/chemokine receptor function and applications in health and disease. Includes materials lists, reproducible protocols, pitfalls and more.
This Methods in Molecular Biology book offers experimental models and state-of-the-art methods used to delineate chemokine/chemokine receptor function...
