This book is related to a study where binding of Losartan Potassium and Valsartan, two anti-hypertensive drugs to Bovine Serum Albumin (BSA)were studied by Equilibrium Dialysis Method.The binding of Losartan Potassium and Valsartan was characterized by two sets of Association Constants.Losartan Potassium showed slightly higher affinity towards BSA than Valsartan.Different analyses of binding to BSA suggested the presence of one high affinity site and four to five low affinity sites for Losartan Potassium and Valsartan.Site-specific probe displacement data implied that both Losartan Potassium...

This book is related to a study involving development and in vitro evaluation of sustained release pellets of ambroxol hydrochloride prepared by extrusion spheronization followed by fluid bed coating with the commercial aqueous polyvinyl acetate dispersion (Kollicoat SR 30 D); aqueous dispersion of ethyl acrylate and methyl methacrylate (Eudragit NE 30 D) and aqueous dispersion of acrylic and methacrylic acid esters (Eudragit RL 30 D and Eudragit RS 30 D). The release of ambroxol hydrochloride from coated pellets was investigated at different coating level. The release mechanism was explored...