Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of...

Famotidine is histamine -H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass...

In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time, Wetting time, Water absorption, T50 (Time required to 50% drug release) and Q10 (percentage of drug released in 10 min.) taken as responses. Solid dispersion showed significant...

Itopride, a novel prokinetic agent is unique and different from the available prokinetics because of its dual mode of action and lack of significant drug interaction potential. Itopride is a newly developed prokinetic agent, which enhances gastric motility through both anti-dopaminergic and anti-acetylcholinesterage actions. It is best candidate for Gastro Esophageal Reflux Disease. Itopride 50mg can be given thrice in a day for Treatment of GERD. By developing the sustain release formulation of Itopride hydrochloride, the frequency of drug can be reduce to once only to obtain good...

Metoprolol Tartrate is a -blocker drug indicated for the treatment of angina, prevention of myocardial infarction, Essential hypertension; It has low bioavailability of about 40% due to hepatic metabolism. The purpose of this research was to improve the bioavailability by preparing a fast dissolving tablet using superdisintegrants method. Because pregastric absorption of drug improves bioavailability, gives rapid onset of action when needed."

Venlafaxine Hydrochloride is an oral antidepressant agent of the Serotonin-Norepinephrine Reuptake Inhibitor class. Venlafaxine Hydrochloride has been studied for the treatment of panic disorder, post-traumatic stress disorder, and the treatment of hot flashes in patients who cannot or do not want to take hormone replacement therapy. The dose of Venlafaxine hydrochloride ranges from 75 to 225 mg three times a day and it undergoes extensive first pass metabolism hence it has only 45% bioavaibility. The short half life of the drug 5 hr indicates the need for modified release dosage form. ...

The aim of this study was to develop a new intra-gastric oating in situ gelling system for controlled delivery of levetiracetam for the treatment of partial onset seizures.High dose of levetiracetam (750 to 1000 mg) is di cult to incorporate in oating tablets but can easily be given in liquid dosage form. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which drug and calcium carbonate were added. A 32 full factorial design was used for optimization. The concentrations of sodium alginate (X1) and calcium...

The purpose of this research was to formulate tasteless complexes of Fexofenadine Hydrochloride with Kyron-134 and to formulate tasteless complex into fast-Dispersible tablets (FDT) for the treatment of allergic rhinitis & chronic idiopathic urticaria. Drug release from FDT in salivary pH was insufficient to impart bitter taste. Complete drug release was observed at gastric pH. The studies indicate that the formulation was taste masked drug can be formulated in to FDT with view to enhance patient compliance & to obtain faster onset action of the drug which would be advantageous in comparison...

To develop sustained release matrix tablet of Tramadol HCl that deliver drug for 24 hr and to be taken once in a day. Drug having high solubility and relatively shorter half-life suggests its suitability for an extended formulation. If it is formulated by conventional tablets, it will require multiple daily administrations which ultimately results into inconveniency to the patients and possibility of reduced compliance with prescribed therapy. Also fluctuation in plasma drug concentration leads to exaggerated side effects, this all limitations can be minimized by adopting extended release...

Indians are genetically more susceptible to diabetes and the W.H.O predicts the number of diabetes in India would go up to 40 million by 2010 and 74 million by 2025. Diabetes is associated with long-term complications that affect almost every part of the body. However Insulin administration is effective to some extent in increasing the life expectation of diabetic patients, but there are wide spectrum of limitations as well as draw backs for this therapy. Some Oral hypoglycemic agents are also employed in this regard, such as renal damage and neurological disturbances. There are great deals...