Wound is defined simply as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissue. Attention should be directed towards discovering an agent, which will accelerate wound healing either when it is progressing normally, when it is suppressed by various agents like corticosteroids, anti neoplastics.or non- steroidal anti-inflammatory agents. Medical treatment of wound includes administration of drugs either locally (topical) or systemically (oral or parenteral) in an attempt to aid...

The aim of this study was to develop a depot formulation of mirtazapine by w/o emulsification method using chitosan as controlled release biodegradable polymer. Chitosan microspheres are used to provide controlled release of mirtazapine and to improve the bioavailability of degradable substances or enhance the uptake of hydrophilic substances across the epithelial layers. The effect of various parameters, such as stirring rate, drug to chitosan ratio, chitosan concentration and glutaraldehyde concentration on entrapment efficiency and release study was studied. Stirring speed affects the size...

Quantitative structure activity relationship studies are indubitably of great importance in modern chemistry. In pursuit of better anti-cancer agents QSAR studies were performed on a series of pyrrolo-benzodiazepine derivatives. The models were developed using training set compounds employing multiple linear regression and partial least square with many descriptors like electronic, topological, and geometrical. The developed models were evaluated for statistical significance and predictive power