These volumes present the results of two studies undertaken for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities. The aim was to review available data concerning the metabolism of a selection of toxic chemi- cals in man and to develop mathematical models representing this meta- bolism. Volume 1 is the report from the first study and presents re- views of the data for each of the substances and proposes models for their metabolic behaviour. Volume 2 is the report of the second study and contains a review of new data relevant to...

This report contains the results of a study undertaken by Associated Nuclear Services (ANS) for the Directorate General of Employment, Social Affairs and Education of the Commission of the European Communities (CEC). This study was entitled "Dynamics of Selected Toxic Materials in Man." vii 2 Summary This report presents results from the second phase of a study on the metabolism of selected actual and potential human carcin ogens. In the first phase of this work a comprehensive review of literature relating to the metabolism of these materials was under taken and pharmacokinetic models were...