Non-invasive imaging of transgene expression should
soon play a critical role in gene and adoptive
cellular gene therapy clinical trials. Positron
emission tomography (PET) reporter genes (PRG)/probes
(PRP) are currently the most advanced technologies
available for imaging transgens in humans. PRGs can
be used to image the location, magnitude, and time
variation of the intensity of transgene expression
throughout the whole body of a patient. This can
eliminate the need for multiple biopsies, which are
potentially dangerous and yet do not provide a
complete picture of whole body transgene...