During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas biochemical pathology and molecular genetics combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative...
During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these ...
Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. Because they are very small and highly dynamic, it is very difficult to study them with traditional techniques. Fortunately, recent ground-breaking advances in optical microscopy (e.g. STED, PALM, STORM, SIM) have greatly improved our ability to image living synapses at the nanoscale, even down to the level of single molecules. The proposed volume brings together leading researchers to review these exciting new techniques and their...
Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and dis...
With chapters contributed by leading innovators in the field of bioimaging, this volume covers the super-resolution methods which are beginning to transform neurobiological research on synapses, which hold the key to understanding higher-brain functions.
With chapters contributed by leading innovators in the field of bioimaging, this volume covers the super-resolution methods which are beginning to tra...
