The cutting-edge development of using a computational design approach as a means of engineering proteins with novel functions has led to widespread usage of computational analysis in protein engineering at large. However, because the structure and function of protein molecules are coupled at the molecular level, many critical questions are left unanswered and many of the intricate design rules unclear. This book furthers understanding in this complex design area by using lucid description of computation's role in protein engineering and tracing the history of protein design. In so doing, it...